Introduction
Instruction Manual, Sep-18
3
1
Introduction
1.1
Intended use of the equipment
The main function of the DBS-MS500 is the fully automated solvent extraction of dried
blood spot samples for detection by a mass spectrometer. The samples are delivered on
cards, with up to four spots per card. To ensure reliable automated sample extraction and
handling, these cards are stored in removable racks which hold them in exactly defined
positions inside the instrument. The instruments handling module picks cards out of the
rack and carries them to an image processing system and then to an optional station for
the application of the internal standard before delivering the card to the extraction unit.
Finally, the sampled cards are stored back in the rack position they were picked from.
With the image processing system, multiple quality factors and identification features of
each card will be measured and checked to ensure the correct spot is sampled and that
this spot has not been incorrectly spotted, or previously sampled. The exact positioning of
the card in the extraction unit will be made according to these values. The optional IS
working solution will be applied at the internal standard station to only the sample to be
extracted. At the extraction unit the analyte will be eluted out of the card using the
preferred solvents (specific extraction solvent mixture). This extract will then be delivered
to the HPLC-MS system for further separation and detection as required. Handling and
extraction processes are to be designed for maximum robustness and minimum carryover.
1.2
Basic overview
Fig. 1: The DBS-MS 500, Overview of functionalities
Summary of Contents for DBS-MS 500
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