9.1 Troubleshooting guide
If the Kvick Lab holder does not seem to work properly, consult the troubleshooting guide (see the
Table below).
Table 9.1: Kvick Lab holder troubleshooting guide
Symptom
Possible Cause
Solution
Holder leaks from between
flow manifold and backing
plate
Insufficient clamping force
Check tie rod nut torque
System is being run at
excessive operating pressures
Run system at proper
operating pressures
Cassette gasket damaged or
not seated properly
Remove and inspect gasket.
Reinstall gasket.
Cassette sealing surfaces
damaged
Remove and inspect sealing
surfaces on the cassette.
Replace cassette if necessary.
Sealing surface of the flow
manifold or backing plate
scratched
Inspect sealing surface of flow
manifold and backing plate for
scratches. Replace or have
Cytiva polish the scratched
surface.
Process solution leaks from
sanitary connections
Sanitary connection gasket
missing, worn, damaged,
improperly mounted, or wrong
size
Inspect gasket for wear,
damage, and proper sizing.
Reinstall gasket.
Sanitary clamp loose
Tighten sanitary clamp
Feed pressure is too high
Cassette fouled
Clean cassette
Obstruction in feed line or
retentate line
Inspect lines for obstruction
Feed inlet in cassette plugged
Switch feed and retentate
lines to reverse flow, and flush
with DI water or WFI Retorque
tie rod nuts
System leaks during integrity
testing
Insufficient clamping force
Locate leaking area by feeling
air leak with hand, or by
applying soapy water and
looking for bubbles. Remove,
inspect, and reinstall cassette
and gasket
Improperly seated cassette or
gasket
9 Troubleshooting
9.1 Troubleshooting guide
Learning to Use the Kvick Lab Cassette Holder User Manual 18117269 AI
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