Product name: DOWFROST
™
Heat Transfer Fluid
Issue Date:
01/23/2015
Page 7 of 11
Serious eye damage/eye irritation
May cause slight temporary eye irritation.
Corneal injury is unlikely.
Sensitization
For the major component(s):
Did not cause allergic skin reactions when tested in humans.
For respiratory sensitization:
No relevant data found.
Specific Target Organ Systemic Toxicity (Single Exposure)
Evaluation of available data suggests that this material is not an STOT-SE toxicant.
Specific Target Organ Systemic Toxicity (Repeated Exposure)
In rare cases, repeated excessive exposure to propylene glycol may cause central nervous system
effects.
Carcinogenicity
Similar formulations did not cause cancer in laboratory animals.
Teratogenicity
For the major component(s): Did not cause birth defects or any other fetal effects in laboratory
animals.
Reproductive toxicity
For the major component(s): In animal studies, did not interfere with reproduction. In animal studies,
did not interfere with fertility.
Mutagenicity
In vitro genetic toxicity studies were negative. For the major component(s): Animal genetic toxicity
studies were negative.
Aspiration Hazard
Based on physical properties, not likely to be an aspiration hazard.
12. ECOLOGICAL INFORMATION
Ecotoxicological information on this product or its components appear in this section when such data
is available.
Toxicity
Propylene glycol
Acute toxicity to fish
Material is practically non-toxic to aquatic organisms on an acute basis
(LC50/EC50/EL50/LL50 >100 mg/L in the most sensitive species tested).
LC50, Oncorhynchus mykiss (rainbow trout), static test, 96 Hour, 40,613 mg/l, OECD Test
Guideline 203
Acute toxicity to aquatic invertebrates
