Labconco FreeZone Plus, Manual

Page 1: ...ments 10 Chamber or Manifold Requirements 11 Space Requirements 11 Your Next Step 11 CHAPTER 3 GETTING STARTED 13 Unpacking Your Freeze Dryer 14 Freeze Dryer Components 14 Setting Up Your Freeze Dryer...

Page 2: ...Recorder Jack 31 Computer Connection 32 CHAPTER 7 TROUBLESHOOTING 35 Vacuum Leak Detection 36 Refrigeration Module Operation 37 APPENDIX A FREEZE DRYER COMPONENTS 39 APPENDIX B FREEZE DRYER DIMENSION...

Page 3: ...f this product will result in many years of dependable service Freeze Dry Process Dehydration is an important process for the preservation and storage of biologicals pharmaceuticals and foods Of the v...

Page 4: ...orize the water and the heat removed from the collector to convert the water vapor into ice Freeze Dry Rates The efficiency of the freeze drying process is dependent upon the surface area and the thic...

Page 5: ...eze dry flask should be two to three times the volume of the sample In order for lyophilization to occur ice must be removed from the frozen sample via sublimation This is accomplished by the collecto...

Page 6: ...factors the eutectic temperature is the most important factor in determining the amount of sample that can be freeze dried at one time particularly when flasks are used This is because as the eutectic...

Page 7: ...e substances will have a greater tendency to melt particularly when placed in flasks or exposed to room temperature If a sample containing a volatile substance tends to melt when placed on a freeze dr...

Page 8: ...ttach a recorder or computer for monitoring the operation Chapter 7 Troubleshooting contains a table of problems you may encounter while using your Freeze Dryer including the probable causes of the pr...

Page 9: ...in injury to the user or permanent damage to your Freeze Dryer Important information is presented in capitalized type in paragraphs that are preceded by the pointer icon It is imperative that the inf...

Page 10: ...l 816 333 8811 Chapter 1 Introduction For information on making modifications to the configuration of your Freeze Dryer go to Chapter 6 Modifying Your Freeze Dryer Refer to Chapter 7 Troubleshooting i...

Page 11: ...e you intend to install your Freeze Dryer You must be certain that the area is level and of solid construction An electrical source must be located near the installation site Carefully read this chapt...

Page 12: ...e Dryer should be located in an area that provides an unobstructed flow of air around the cabinet This air cools the refrigeration system The refrigeration system draws air through the grill on the fr...

Page 13: ...acuum pumps available from Labconco Chamber or Manifold Requirements A freeze drying chamber or manifold must be purchased separately These allow samples to be attached to the Freeze Dryer See Appendi...

Page 14: ...12 Product Service Domestic 1 800 522 7658 International 816 333 8811 Chapter 2 Prerequisites...

Page 15: ...ze Dryer Read this chapter to learn how to unpack and move your Freeze Dryer set up your Freeze Dryer connect the electrical supply source to your Freeze Dryer properly exhaust your Freeze Dryer safel...

Page 16: ...WAS DAMAGED IN TRANSIT YOU MUST FILE A CLAIM DIRECTLY WITH THE FREIGHT CARRIER LABCONCO CORPORATION AND ITS DEALERS ARE NOT RESPONSIBLE FOR SHIPPING DAMAGE Do not discard the carton or packing materia...

Page 17: ...eeze Dryer to the location where you want to install it Then follow the steps listed below Component Orientation Hose Connections The refrigeration system in the Freeze Dryer exhausts air through the...

Page 18: ...vacuum is applied to the system the chamber will be held securely in place Drying Manifold Installation If a drying manifold is to be installed first place the accessory acrylic attachment port lid 74...

Page 19: ...stances used in connection with this equipment may be governed by various Federal State or local regulations All users of this equipment are urged to become familiar with any regulations that apply in...

Page 20: ...18 Product Service Domestic 1 800 522 7658 International 816 333 8811 Chapter 3 Getting Started...

Page 21: ...ed in Chapter 3 Getting Started you are ready to begin using your Freeze Dryer Read this chapter to learn how to operate the controls understand the display connect samples Do not use the Freeze Dryer...

Page 22: ...ed are system vacuum 10 3 mBar and collector temperature C Displays type of alarm when an alarm has occurred 3 Menu Switch This switch is used to change the display from system parameters to alarm mes...

Page 23: ...en LED indicates that the Freeze Dry unit is in the Auto Mode In this mode the vacuum pump will start when the collector temperature reaches 40 C 8 Auto Mode Switch Used to start or stop the refrigera...

Page 24: ...ing chamber manifold to remove any dirt and contaminants that could cause a vacuum leak Reinstall the drying chamber or manifold on the port Vacuum grease is not required on the port gasket to obtain...

Page 25: ...perature the vacuum pump may be started by pressing the vacuum switch Adding Sample The following procedure should be followed when freeze drying samples with a drying chamber or manifold 1 Pre freeze...

Page 26: ...ce of the sample container and no cold spots can be detected by handling the container the sample is nearly dry To be certain of low final moisture content dry the sample for several hours past this p...

Page 27: ...events occur during a run the alarm LED will illuminate to notify the user 1 Power Interruption If the power to control system is interrupted either by a power failure or by turning the main power sw...

Page 28: ...arms if they have occurred The alarm indicator can be cancelled by turning the REFRIGERATION off 4 Service Vacuum Pump The vacuum pump normally plugs into the vacuum pump receptacle on the back of the...

Page 29: ...ber 1 Pull the collector chamber drain hose out from the side on the unit and remove the drain plug Place the drain hose in a suitable container to collect the condensate that will be defrosted 2 Remo...

Page 30: ...28 Product Service Domestic 1 800 522 7658 International 816 333 8811 Chapter 4 Using Your Freeze Dryer...

Page 31: ...ge or chamois and a mild non abrasive soap or detergent 3 Check oil level of the vacuum pump if applicable It should be between MIN and MAX If the oil level is less than an inch 25 4 mm above MIN add...

Page 32: ...th sponge or chamois and a mild non abrasive soap or detergent clean the acrylic chamber lid 3 Using a soft cloth sponge or chamois and a mild non abrasive soap or detergent clean the exterior surface...

Page 33: ...der to the Freeze Dryer connect a computer to the Freeze Dryer interpret the data received Recorder Jack The system vacuum and collector temperature can be recorded during operation by connecting an a...

Page 34: ...that supports either a 25 pin D sub male connector or 9 pin D sub male connector for serial communication See Appendix D Freeze Dryer Accessories for available connection cables Computer with a 25 pi...

Page 35: ...listed below 1 Data Rate 2400 Baud 2 8 Bit word length 3 1 Start bit 1 Stop bit 4 No parity is transmitted 5 Standard ASCII character set The data of the transmitted message is as follows 1 The follo...

Page 36: ...lection system is mBAR x 10 3 RFG ON indicates the state of the refrigeration compressor VAC ON indicates the state of the vacuum pump There are several commercially available software packages which...

Page 37: ...will not operate No vacuum Unit not connected to electrical power Connect unit to proper electrical power Pump not on Turn on pump Pump not connected to unit Connect pump to unit Drain hose plug not i...

Page 38: ...roperly and the collector temperature must be 40 C or lower If your Freeze Dryer does not obtain a satisfactory vacuum the following procedure should be used to locate and correct any vacuum problems...

Page 39: ...84 C within 40 minutes then the refrigeration module is not functioning properly The refrigeration system in your freeze dry unit is a cascade type system Simply a cascade system is two vapor compress...

Page 40: ...repairs are required on the refrigeration module contact you local laboratory supply dealer If satisfaction is not obtained through the dealer service network please call Labconco Repairs should only...

Page 41: ...PP PE EN ND DI IX X A A F FR RE EE EZ ZE E D DR RY YE ER R C CO OM MP PO ON NE EN NT TS S The following pages list components that are available for your Freeze Dryer The parts shown are the most com...

Page 42: ...00 Hose Clamp 7 1 7474200 6 Min Delay Timer 115V 7A 1 7474400 6 Min Delay Timer 230V 8 1 7646000 Vacuum Hose 9 1 1336400 Power Cord 115V 9A 1 1337300 Power Cord 230V 10 1 7528900 Fan Blade 11 1 793510...

Page 43: ...41 Product Service Domestic 1 800 522 7658 International 816 333 8811 Appendix A Freeze Dryer Components...

Page 44: ...42 Product Service Domestic 1 800 522 7658 International 816 333 8811 Appendix A Freeze Dryer Components...

Page 45: ...43 Product Service Domestic 1 800 522 7658 International 816 333 8811 A AP PP PE EN ND DI IX X B B F FR RE EE EZ ZE E D DR RY YE ER R D DI IM ME EN NS SI IO ON NS S...

Page 46: ...44 Product Service Domestic 1 800 522 7658 International 816 333 8811 Appendix B Freeze Dryer Dimensions...

Page 47: ...is Appendix contains technical information about the Freeze Dryer including specifications environmental operating conditions and wiring diagrams Electrical Specifications Nominal amperage for 115V Fr...

Page 48: ...ty at 104 F 40 C Main supply voltage fluctuations not to exceed 10 of the nominal voltage Transient overvoltages according to Installation Categories II Overvoltage Categories per IEC 1010 Temporary v...

Page 49: ...47 Product Service Domestic 1 800 522 7658 International 816 333 8811 Appendix C Freeze Dryer Specifications Wiring Diagram 115V Model...

Page 50: ...48 Product Service Domestic 1 800 522 7658 International 816 333 8811 Appendix C Freeze Dryer Specifications Wiring Diagram 230V Model...

Page 51: ...50 60 Hz single phase 7 8 amps 77394 03 Vacuum Pump Two stage direct drive pump 195 liters minute 230 VAC 50 60 Hz single phase 4 0 amps with reverse IEC plug 14721 00 Vacuum Pump Two stage direct dri...

Page 52: ...ia for Soda Acid Trap 77725 00 Charcoal Solvent Trap Secondary trap that prevents migration of organic solvents into vacuum pump 77726 00 Replacement Activated Charcoal Media for Charcoal Solvent Trap...

Page 53: ...oduct Heater For use in chamber 75228 00 Provides 3 heated shelves operating at 43 C 110 F 230V 75223 00 20 Port Manifold 10 high x 27 wide x 8 5 8 deep Type 304 stainless steel manifold with 20 freez...

Page 54: ...52 Product Service Domestic 1 800 522 7658 International 816 333 8811 Appendix D Freeze Dryer Accessories Fast Freeze Flasks...

Page 55: ...53 Product Service Domestic 1 800 522 7658 International 816 333 8811 Appendix D Freeze Dryer Accessories Lyph Lock Flasks...

Page 56: ...54 Product Service Domestic 1 800 522 7658 International 816 333 8811 Appendix D Freeze Dryer Accessories Serum Bottles Vials...

Page 57: ...55 Product Service Domestic 1 800 522 7658 International 816 333 8811 Appendix D Freeze Dryer Accessories Ampules...

Page 58: ...56 Product Service Domestic 1 800 522 7658 International 816 333 8811 Appendix D Freeze Dryer Accessories...

Page 59: ...57 Product Service Domestic 1 800 522 7658 International 816 333 8811...