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Cellicon

TM

 Perfusion Solution for Process Development User Guide 

12

Settings

System Settings

General

Auto-resume

Allows the system to store the current 

system state and setpoint. If power is lost, 

the system recovers automatically when this 

feature is enabled. An alert shows the system 

has recovered its last working point using the 

auto-resume feature.

Date & Time 

Adjust the values up or down. Select 

Done

 

when finished adjusting the values. The date 

and time format is MM-DD-YYYY HH:MM.

Flip Display

Change the orientation of the display to 

landscape, portrait or upside down.

Automatic Standby Mode 

Locks the screen and displays a screensaver 

after a defined period of inactivity (1 to 1000 

minutes). Enable this feature by selecting 

the checkmark next to 

Enable automatic 

standby mode

.

In standby mode, the screensaver shows the 

following information: 

 

Standby Mode with No Active Alerts

Standby Mode with Active Alerts

To unlock the screen, select 

UNLOCK

 and enter 

user account credentials.

Data Logging

The beginning of the filename can be defined 

by adding a log filename. The ending is fixed 

and generated with the date followed by the 

time when the logfile is created.
When data logging is switched 

On

, a prompt 

to enter a filename will appear. This filename 

will replace the text in the log filename 

region in the settings.

A USB drive must be inserted into the controller to 

start the data logging. Data will be lost if the USB 

drive is removed prior to ending the data logging.
The logfile is stored as a csv-file to the 

subfolder/ logs on the USB drive.
The csv-file format allows a user to open the 

logfiles with Microsoft Excel.
The data logging settings also define log 

interval and the log file size. 

Import/Export Settings

Settings can be imported via the USB drive. 

By selecting 

IMPORT

, if any settings file is 

found it will be listed within the selection list 

on the popup window and can be loaded onto 

the controller. Existing controller settings will 

be overwritten by the settings files imported 

from the USB drive.

Import Settings Popup

Export Settings enables a user to store 

all controller settings on a USB drive and 

transfer them to another controller. 

Factory Reset

By selecting 

RESTORE

, all the settings will be 

reset to the factory setting values. 

Note  All the existing controller settings will 

be lost by restoring factory settings.

Summary of Contents for Milipore Cellicon Perfusion Solution for Process Development

Page 1: ...n Solution for Process Development User Guide Contents Introduction 2 System Components 2 Setting Up the System 3 Starting the System 4 User Interface 4 Settings 7 Running the Pump 7 Alerts 9 Settings...

Page 2: ...scribes the installation setup and use of the CelliconTM Perfusion Solution for Process Development This system is for industrial use only and cannot be used in a residential environment System Compon...

Page 3: ...ors on the assembly as follows Press 1 to the feed line Press 2 to the retentate line Press 3 to the perfusate permeate line Connecting the Bioreactor Use a tubing welder to connect The cell retention...

Page 4: ...on Powering up the system launches the perfusion control software The initial screen is the username selection screen After selecting the username the password screen will appear Touch the white box o...

Page 5: ...ton Selecting the Settings button opens the settings screen User Icon and Time Date Display Selecting the user icon allows the user to lock the screen or switch users Lock screen will cause the contro...

Page 6: ...low Setpoint Prime System Zero Adjust Flow Rate Speed Setpoint Pump Start Decrease Flow Rate Increase Flow Rate Status The current values state of the system components and data logging switch are dis...

Page 7: ...ton will read START PUMP If the pump is on the button will read STOP PUMP Stopping the pump will cause a confimation screen to appear Prime System The pump needs to be primed to reduce damage to cells...

Page 8: ...t be stopped A pop up will appear to confirm that the pump is stopped Flowmeter 2 does not require that the pump is stopped All sensors should be zero adjusted prior to starting a run Only one sensor...

Page 9: ...splayed Alarm Acknowledgement Alerts can be removed from the main screen by selecting Acknowledge from the alert bar or in the alert log The alert will reappear on the alert bar if it remains active 1...

Page 10: ...ill make a loud beep when the alert is activated Select Dismiss to return to the main screen then select Acknowledge on the alert bar or within the alert log The data region can still be viewed when a...

Page 11: ...Critical Alarm High Optional 1 Pressure Alarms Pressure Critical Alarm Low Optional 1 Pressure Warning Alarm Low Never 2 Pressure Warning Alarm High Never 2 Pressure Critical Alarm High Optional 1 Al...

Page 12: ...ending is fixed and generated with the date followed by the time when the logfile is created When data logging is switched On a prompt to enter a filename will appear This filename will replace the t...

Page 13: ...error The resolution of the flow signal can be improved by decreasing the full scale of the flowmeter The resolution of the flow signal is always 1 10 000 of the full scale Decreasing the full scale b...

Page 14: ...Refer to Table of Alerts for more information Critical alarms are shown in red color type 1 alert Warning alarms are shown in yellow color type 2 alert Neither critical nor warning alarms will shut d...

Page 15: ...nalog Input PLC Digital Input PLC Analog Output User Accounts Settings The administrator can generate delete and edit user accounts including password protection capabilities and rescrict access permi...

Page 16: ...s have been added to the reactor This will eliminate the possible introduction of cell shear when the system is primed see Priming Preparation Equipment Needs The following user supplied items may be...

Page 17: ...r or gas in the pump head will negatively affect pump performance and decrease the recirculation flow rate MobiusTM 3L Single use Bioreactor When using the MobiusTM single use 3L reactor the inlet to...

Page 18: ...lect Prime system on the main menu screen This will switch the controller into Speed setpoint mode and provide step by step guidance on how to complete the priming 2 Ensure that the perfusate permeate...

Page 19: ...ved on the USB drive the log interval and the log file size Choose a log interval of 60 seconds or greater and a log file size of 65000 lines Insert the USB drive into a computer to view data Open Mic...

Page 20: ...ars light grey and does not read values Connect cables from component to controller Install correct software Component is in an alarm state appears red or yellow Plug in component cables Pump alert Pl...

Page 21: ...d ensure it does not pull air from sparger Check system mode flow control vs speed control No flow through permeate Ensure permeate line is not clamped or pinched Symptom Corrective Action Early filte...

Page 22: ...un Disposing of the Filter The filter is completely single use and should be disposed of after use Follow company procedure for waste disposal Cleaning the Hardware All parts of the system should be w...

Page 23: ...s All other trademarks are the property of their respective owners Detailed information on trademarks is available via publicly accessible resources MK_UG5285EN Rev 1 06 2020 2020 Merck KGaA Darmstadt...

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