Miltenyi Biotec MultiMACS M96, User Manual

Page 1: ...Original instructions MultiMACS M96 Separator User manual...

Page 2: ...ion of this user manual However Miltenyi Biotec shall not be liable for any technical or editorial errors or omissions contained herein or for incidental or consequential damages in connection with th...

Page 3: ...6 Separator User manual Miltenyi Biotec B V Co KG Friedrich Ebert Stra e 68 51429 Bergisch Gladbach Germany Phone 49 2204 8306 0 Fax 49 2204 85197 macsde miltenyi com www miltenyibiotec com Original i...

Page 4: ...in damage to the instrument Improper usage could also cause severe personal injury death unpredictable results instrument malfunction and premature wear to components shortening the lifetime of the i...

Page 5: ...68 Technical data 70 EC EU Declaration of Conformity Chapter 4 72 Installation 72 Safety functions 72 Protective screen 73 Emergency break 73 Unpacking 74 Semi automated bench top use 74 Automated us...

Page 6: ...Editing Plate Height 113 D Advanced parameter types 115 Saving the edited process 116 Testing Plate Height or Distance for Plate Removal 117 Replacing a user defined process 118 Deleting a user define...

Page 7: ...using the MultiMACS M96 Separator This chapter describes the safety instructions and site requirements for your MultiMACS M96 Separator The following warnings and cautions are provided to help you pr...

Page 8: ...rts due to mechanical hazards Strong magnetic field The magnetic field can interfere with magnetizable objects and electronic devices or damage magnetic information carriers Risk of severe personal in...

Page 9: ...al hazards and create a safe work environ ment If this instrument is used in a manner not specified by the manufacturer protection may be impaired Important Please read and follow all operating instru...

Page 10: ...an opened dropped or damaged MultiMACS M96 Separator is used if liquids are spilled into the instrument if an object has entered the instrument through the ventilation slots or if an object has been...

Page 11: ...n moving magnet the physical resistance of the object causes the instrument to tilt backward similar to a hydraulic jack Do not place objects on the MultiMACS M96 Separator Leave a space of at least 2...

Page 12: ...onmentally caused shutdowns Important At all times local working area safety instructions laboratory policies and standards regarding laboratory health and safety and prevention of accidents must be a...

Page 13: ...d earthed product The instrument is equipped with a three wire electrical grounding type plug that has a third pin for grounding This plug only fits into a grounded power outlet This is a safety featu...

Page 14: ...or messages on the display screen advise to contact technical service secure operation is no longer possible Immediately switch off the MultiMACS M96 Separator unplug the instrument from the power ou...

Page 15: ...power outlet before cleaning Do not use liquid or aerosol cleaning agents always use a damp cloth Hazardous material If biohazardous material is or has been used the operator shall choose and wear pe...

Page 16: ...you dispose of your unwanted electrical and electronic equipment according to the applicable WEEE and hazardous waste disposal legislation you are helping to preserve our natural resources and protect...

Page 17: ...ans un endroit s r et accessible aux utilisateurs de MultiMACS M96 Separator Ce chapitre d crit les consignes de s curit et les exigences d installation s appliquant votre MultiMACS M96 Separator Les...

Page 18: ...nt et de cisaillement Risque d crasement et de cisaillement des membres corporels d des dangers m caniques Champ magn tique puissant Le champ magn tique interf re avec les objets magn tisables et les...

Page 19: ...apitre expliquent les risques potentiels li s l utilisation de l appareil et fournissent des informations de s curit importantes afin de r duire ces risques En respectant pr cautionneusement ces consi...

Page 20: ...ectrocution n ouvrez aucun cache du MultiMACS M96 Separator ni d autres quipements accessoires fournis par Miltenyi Biotec Tous les caches de l appareil et des quipements accessoires doivent tre d mon...

Page 21: ...n tique y compris tout autre aimant ou cran MultiMACS au del d une certaine distance de s curit Risque d crasement et de cisaillement Tray in motion during operation Hazard of crushing fingers Operate...

Page 22: ...urit sur l appareil Veuillez noter les emplacements des consignes de s curit sur le MultiMACS M96 Separator et veillez ce que les consignes soient parfaitement lisibles S curit de l installation Ce pa...

Page 23: ...pour accueillir l appareil qu une ventilation appropri e est garantie et que les instructions de montage relatives l appareil ont t respect es Circulation de l air Ne placez pas l appareil proximit d...

Page 24: ...ons sur le type de courant lectrique que vous pouvez utiliser contactez votre prestataire de services Miltenyi Biotec agr ou votre fournisseur d lectricit local N utilisez pas de rallonges ni de barre...

Page 25: ...ien du MultiMACS M96 Separator sauf autre consigne sp cifique donn e dans ce mode d emploi ou dans un autre document de Miltenyi Biotec L entretien et la r paration doivent tre effectu s par des r par...

Page 26: ...porter un quipement de protection individuelle conforme aux avertissements et aux pr cautions pour les substances utilis es Portez des gants de protection des v tements de protection et des lunettes...

Page 27: ...ts lectriques et lectron iques en accord avec la directive DEEE et la l gislation applicable relative l limination des d chets dangereux vous contribuez la pr servation des ressources naturelles et la...

Page 28: ...27...

Page 29: ...f zug nglich f r jeden Anwender des MultiMACS M96 Separators Dieses Kapitel beschreibt die Anforderungen an den Ger testandort und die Sicherheitsvorschriften Ihres MultiMACS M96 Separators Die folgen...

Page 30: ...von K rperteilen verursacht werden Starkes Magnetfeld Das Magnetfeld kann auf andere magnetisch aufladbare Gegenst nde und elektronische Ger te st rend einwirken oder magnetische Datentr ger besch dig...

Page 31: ...f ltig befolgt sch tzen Sie sich und das Ger t vor m glichen Gef hrdungen und schaffen so ein sicheres Arbeitsumfeld Sollte das Ger t entgegen den Vorgaben des Herstellers eingesetzt werden so k nnte...

Page 32: ...bdeckungen sowie das Ger te Zubeh r d rfen nur von geschultem Personal entfernt werden Besondere Vorsicht ist geboten beim Umgang mit Fl ssigkeiten Beseitigen Sie ausgetretene oder versch ttete Fl ssi...

Page 33: ...in motion during operation Hazard of crushing fingers Operate only with attached protection screen Device must be able to be tilted backwards Warnung Halten Sie die Finger fern von allen beweglichen T...

Page 34: ...die Anleitungen in diesem Abschnitt und stellen Sie sicher dass der Ger testandort entsprechend vorbereitet ist bevor Sie das Ger t in Betrieb nehmen Ber cksichtigen Sie bei der Aufstellungsplanung di...

Page 35: ...ollten niemals bedeckt oder blockiert werden da sie das Ger t vor berhitzung sch tzen und sicheren Betrieb erm glichen F hren Sie niemals Fremdk rper durch ffnungen in das Ger t ein Wassereintritt und...

Page 36: ...lgenden Hinweise bez glich Betriebssicherheit Wartung Transport und Entsorgung Ihres MultiMACS M96 Separators Wichtig rtliche Arbeitsschutzbestimmungen Laborrichtlinien Sicherheitsnormen und Unfallver...

Page 37: ...tionen oder Sch den am Ger t die auf Verwendung ungeeigneter Verschlei oder Ersatzteile zur ckzuf hren sind Nach jedweder erfolgter Wartungs oder Reparaturleistung lassen Sie Ihren autorisierten Milte...

Page 38: ...ischen Gefahrenstoffen Wenn Sie Fragen zur vorschriftsm igen Dekontaminierung oder zum Versand des Ger tes haben wenden Sie sich bitte direkt an unseren Technical Support Entsorgung Kundeninformation...

Page 39: ...n Sie dass je nach Art und Nutzung Ihres Ger tes zus tzliche Anforderun gen gelten k nnen Bevor Sie das Altger t an den Hersteller zur Entsorgung zur cksenden dekontaminieren Sie es um s mtliche gef h...

Page 40: ...39...

Page 41: ...luogo sicuro accessibile a tutti gi addetti che utilizzano l unit di il MultiMACS M96 Separator Il presente capitolo illustra le istruzioni di sicurezza e i requisiti ambientali per l installazione de...

Page 42: ...aglio Rischio di schiacciamento o di taglio di parti del corpo a causa di componenti meccanici Forte campo magnetico Il campo magnetico pu interferire con oggetti magnetizzati e dispositivi elettronic...

Page 43: ...nziali rischi associati al funzionamento dello strumento e forniscono importanti informazioni in materia di sicurezza atte a ridurre al minimo detti rischi Seguendo scrupolosamente le istruzioni possi...

Page 44: ...CS M96 Separator n altri accessori hardware forniti da Miltenyi Biotec Tutti gli altri coperchi dello strumento e gli accessori hardware possono essere rimossi esclusivamente da personale autorizzato...

Page 45: ...g operation Hazard of crushing fingers Operate only with attached protection screen Device must be able to be tilted backwards Warning Tenere le dita ecc lontano da tutte le parti in movimento dello s...

Page 46: ...rator onde garantirne un installazione sicura e il funzionamento corretto Leggere le istruzioni fornite nella presente sezione e accertarsi che il luogo prescelto sia adeguatamente predisposto prima d...

Page 47: ...ultiMACS M96 Separator mantenendo uno spazio libero di almeno 15 cm su ogni lato durante il funzionamento onde assicurare un adeguato raffreddamento dello strumento Evitare l esposizione diretta ai ra...

Page 48: ...re RS232 contrassegnato con com Collegare unicamente apparecchi MultiMACS originali ai connettori contrassegnati con module 1 e module 2 e il display MultiMACS al connettore contrassegnato con display...

Page 49: ...che il tecnico utilizzi unicamente pezzi di ricambio originali Miltenyi Biotec o ricambi di altri fabbricanti specificati e raccomandati da Miltenyi Biotec L impiego di pezzi di ricambio non autorizza...

Page 50: ...llaggi specificati da Miltenyi Biotec In caso di cadute o di vibrazioni eccessive lo strumento pu subire dei danni interni Qualora si renda necessario rispedire lo strumento al produttore per interven...

Page 51: ...notare che a seconda del tipo e dell utilizzo delle apparecchiature possono essere necessari requisiti aggiuntivi Prima di rispedire lo strumento al produttore per lo smaltimento decontaminare lo str...

Page 52: ...51...

Page 53: ...a Mantenga este manual de usuario en un lugar seguro al alcance de todo aquel que est usando el MultiMACS M96 Separator El presente cap tulo describe las instrucciones de seguridad y los requisitos d...

Page 54: ...nales graves o la muerte Peligro de aplastamiento o corte Riesgo de que se aplaste o corte alguna parte del cuerpo debido a peligros mec nicos Campo magn tico intenso El campo magn tico puede interfer...

Page 55: ...e a fin de reducir dichos riesgos al m nimo Si sigue cuidadosamente las instrucciones se proteger a s mismo y al equipo de posibles peligros y crear un ambiente de trabajo seguro Si este instrumento e...

Page 56: ...enyi Biotec Cualquier cubierta asi como hardware accesorios deber n ser retirados nicamente por personal autorizado Se debe tener especial cuidado cuando se manejen l quidos Limpie inmediatamente los...

Page 57: ...as partes del cuerpo alejados de las partes m viles del MultiMACS M96 Separator para evitar que sufran aplastamientos y o cortaduras o que el instrumento sufra da os Si alg n objeto ha sido colocado p...

Page 58: ...las precauciones recogidas en este cap tulo para evitar aver as del instrumento y reducir la posibilidad del cierre de la empresa por razones medioambientales Importante En todo momento se debe observ...

Page 59: ...introduzca ning n cuerpo extra o por las aberturas del instrumento Agua y humedad No use el instrumento en un lugar h medo Evite la elevada humedad o la condensaci n y proteja a la m quina de salpica...

Page 60: ...la etiqueta display Manejo mantenimiento transporte y eliminaci n seguros Observe las siguientes instrucciones para asegurar un manejo mantenimiento transporte y eliminaci n de su MultiMACS M96 Separ...

Page 61: ...es de Miltenyi Biotec o de otros fabricantes especificados y recomendados por Miltenyi Biotec El uso de piezas de recambio o de repuesto no autorizadas puede producir un mal funcionamiento del aparato...

Page 62: ...Miltenyi Biotec Se pueden producir da os internos si es expuesto a vibraciones excesivas o si se cae En caso de que sea necesario devolver el instrumento a su fabricante para su revisi n l mpielo y de...

Page 63: ...uisitos reglementarios Tenga en cuenta que dependiendo del tipo y uso del equipo pueden aplicarse requisitos adicionales Antes de devolver el instrumento al fabricante para que lo deseche descontamine...

Page 64: ...63...

Page 65: ...moved vertically up and down together with or independent from the MultiMACS Column Holder Thereby either lowering of the columns into the wells of the magnet or the lifting of the columns out of the...

Page 66: ...ells of the plates Before removal of a plate or separation of magnet and columns any drop on the column tips has to be taken off This avoids contamination of the magnet cross contamination between sam...

Page 67: ...s added to the sample then the MicroBead labeled sample is applied to the Multi 8 96 Column Placed in the strong magnetic field of the MultiMACS 96 Magnet the labeled molecules are retained in the mag...

Page 68: ...67...

Page 69: ...ure 15 30 C Humidity 0 85 Altitude max 2000 m Emission sound pressure level at workstation 70 dB A Table 3 1 Technical data of the MultiMACS M96 Separator The MultiMACS M96 Separator is labeled as a p...

Page 70: ...ference will not occur in a particular installation If this equipment does cause harmful interference to radio or television reception which can be determined by turning the equipment off and on the u...

Page 71: ...The declaration of conformity refers to the machinery identified as follows Description Laboratory equipment Model MultiMACS M96 Separator The machinery complies with all essential requirements of the...

Page 72: ...71...

Page 73: ...ode Remove the Protective Screen only if used in liquid handling platforms as it can interfere with gripping plates In case the Protective Screen is tilted while moving upwards a light barrier detects...

Page 74: ...h Plate and the magnet Do not reach between the magnet and the Column Holder while the magnet is moving To stop the movement and halt the process in case of danger accident or malfunction touch anywhe...

Page 75: ...ge 65 3 Connect the power cable to the outlet on the rear side of the MultiMACS M96 Separator and to an appropriate electrical socket Automated use in liquid handling platforms The MultiMACS M96 Separ...

Page 76: ...75...

Page 77: ...treptavidin Kit 12 8 4 96 130 092 948 130 092 949 MultiMACS Protein A Kit 24 8 4 96 130 092 944 130 092 945 MultiMACS Protein G Kit 24 8 4 96 130 092 946 130 092 947 MultiMACS VitalVirus HIV Isolation...

Page 78: ...he Deep Well Block 2 5 mL it is 44 mm The Tip Touch Plate of the MultiMACS M96 Separator is designed for the footprints of microtiter plates that comply to ANSI SBS standards length 127 76 mm 0 5 mm w...

Page 79: ...commended for transferring liquids without foaming Appropriate reagent reservoirs If the target is eluted from MicroBeads with hot elution buffer Heatable reagent reservoir e g heating block or a ther...

Page 80: ...79...

Page 81: ...r of Flow through Plates Preference items Exchange magnet Lock instrument for transport Version of firmware Beep on off Process Management Screen Multi8 96 Pos 96 POS VIEW EDIT ESC Setup Screen PREFER...

Page 82: ...screen without execution of the step indicated on the display Tray in motion during operation Hazard of crushing fingers Operate only with attached protection screen Device must be able to be tilted b...

Page 83: ...vidin Kit applications If a process with different process parameters must be run either create a new process as described in chapter 6 Creating a new user defined process Or if only a few parameters...

Page 84: ...ted backwards 3 Touch to run the process and the magnet will move to the start position Then follow the instructions given on the Touch Display INSERT MULTI 8 96 COLUMNS MOVE BACK OK ESC 4 Insert a Mu...

Page 85: ...K ESC 6 Rinse columns with equilibration buffer apply sample and wash A pre elution might be required to exchange the void volume of the column refer to the respective kit data sheet for detailed inst...

Page 86: ...oirs of the columns without touching the rims and apply elution buffer directly onto the Multi 8 96 Column matrix Touch OK for the next screen TIP TOUCH COLUMNS IN PLATE OK ESC 10 Wait approximately o...

Page 87: ...e it according to protocol Touch OK and the MultiMACS 96 Magnet moves apart from the Column Holder REMOVE COLUMNS TOUCH OK TO END PROCESS MOVE BACK OK ESC 12 Remove MultiColumn Frame with Multi 8 96 C...

Page 88: ...ed as waste plate or flow through plate For purchase of additional Deep Well Blocks refer to chapter 5 Reagents columns and plates If a process with different process parameters has to be run either c...

Page 89: ...with up to twelve Multi 8 Columns or a pre packed Multi 96 Column into the MultiMACS Column Holder Touch OK and the magnet will move upwards and unlock the MultiMACS Column Holder The following screen...

Page 90: ...fall off by gravity 7 Touch OK and the MultiMACS 96 Magnet will move upwards to allow insertion of the flow through plate INSERT FLOWTHRU PL 1 OF 2 DWB 44 MM MOVE BACK OK ESC Insert flow through plate...

Page 91: ...l of the flow through plate INSERT FLOWTHRU PL 2 OF 2 DWB 44 MM MOVE BACK OK ESC 11 Insert flow through plate If using a plate with a different height adjust the height of the flow through plate as de...

Page 92: ...ome wells were not used pour off waste liquid and store plate Insert an elution plate Microtiter Plate included in MultiMACS Kits If using a plate with a different height adjust the height of the elut...

Page 93: ...ackwards Touch OK and the MultiMACS 96 Magnet moves upwards to allow removal of the elution plate Microtiter Plate REMOVE ELUTION PLATE MOVE BACK OK ESC 17 Remove elution plate and use samples for dow...

Page 94: ...net If a process with different process parameters has to be run either create a new process as described in chapter 6 Creating a new user defined process or if only a few parameters have to be change...

Page 95: ...tructions given on the Touch Display INSERT MULTI 8 96 COLUMNS MOVE BACK OK ESC 4 Insert a MultiColumn Frame with up to twelve Multi 8 Columns or a pre packed Multi 96 Column into the MultiMACS Column...

Page 96: ...the Multi 8 Columns This process removes any drop on the column tips that did not fall by gravity Touch OK to move the MultiMACS 96 Magnet upwards and to allow removal of the waste plate REMOVE WASTE...

Page 97: ...nstrument and touch the Welcome Screen or wait for a few seconds for the Process Selection Screen WELCOME TO THE MULTIMACS SEPARATOR BY MILTENYI BIOTEC 96 POS NEW 96 NEG POS SET UP 2 Touch NEW and the...

Page 98: ...or Plate Removal D2 Number of Flow through Plates A Selecting Fraction of Interest First you have to select the desired fraction after magnetic labeling of samples The positive labeled fraction the ne...

Page 99: ...TION or BOTH FRACTIONS were chosen for the fraction of interest two options for the elution of target molecules are possible SELECT ELUTION MODE ELUTION IN SIDE MAGNET ESC To retain the MicroBeads wit...

Page 100: ...ration buffer flow through and wash buffer Eluate COLLECT NEG FRACTION Equilibration buffer Flow through wash buffer COLLECT BOTH Equilibration buffer Flow through wash buffer Eluate Flow through and...

Page 101: ...NTER HEIGHT ESC SELECT FLOWTHRU PL ENTER HEIGHT ESC SELECT ELUTION PLATE ENTER HEIGHT ESC 3 Touch ENTER HEIGHT for the next screen 30 0 MM 0 5 MM 5 MM OK 0 5 MM 5 MM ESC TEST Touch 0 5 MM or 5 MM to i...

Page 102: ...electing Distance for Plate Removal The Distance for Plate Removal is the distance the magnet moves up to create space to remove a plate and to insert a new one DISTANCE FOR PLATE REMOVAL PLATE REMOVA...

Page 103: ...through Plates 1 If COLLECT NEG FRACTION or COLLECT BOTH FRACTIONS was chosen as the fraction of interest the flow through and each wash buffer fractions can be collected separately by increasing the...

Page 104: ...g a user defined process After saving the following screen appears SAVE PROCESS TO LIST SAVE ESC 2 Touch YES to start the process or NO to go back to the Welcome Screen DO YOU WANT TO START THIS PROCE...

Page 105: ...d on the MultiMACS is displayed in the upper left default 96 POS 2 If necessary scroll through the list of available process names by touching the symbol or until the desired process is displayed Touc...

Page 106: ...MACS is displayed in the upper left default 96 POS The one but last process is listed below 2 If necessary scroll through the list of available process names by touching the symbol or until the desire...

Page 107: ...OS FRACTION ESC 96 POS NEW 96 NEG POS ESC The last process performed on the MultiMACS M96 Separator is displayed in the upper left default 96 POS 2 If necessary scroll through the list of available pr...

Page 108: ...where a new process name has to be entered ENTER NAME A_ OK ABC DEF GHI DEL 6 Touch the ABC box once to enter an A press twice for a B and three times for a C Touch the box multiple times if necessar...

Page 109: ...ng the symbol or until the desired parameter is displayed EDIT FRACTION OF INTEREST COLLECT BOTH FRACTION ESC 3 Touch the parameter to select it e g COLLECT BOTH FRACTIONS If COLLECT POS FRACTION is c...

Page 110: ...TSIDE MAGNET is displayed The current process parameter is displayed on the lower left of the Touch Display EDIT PROCESS MY_OWN_PROG ELUTION IN SIDE MAGNET ESC 3 To change the parameter of the paramet...

Page 111: ...terest WASTE PLATE to collect FLOWTHRU PLATE to collect ELUTION PLATE to collect COLLECT POS FRACTION Equilibration buffer flow through and wash buffer Eluate COLLECT NEG FRACTION Equilibration buffer...

Page 112: ...he Touch Display Below all three screens are listed EDIT PROCESS MY_OWN_PROG ELUTION PLATE MTP 14 MM ESC EDIT PROCESS MY_OWN_PROG FLOWTHRU PLATE DWB 44 MM ESC EDIT PROCESS MY_OWN_PROG WASTE PLATE DWB...

Page 113: ...ION PLATE ENTER HEIGHT ESC EDIT WASTE PLATE ENTER HEIGHT ESC 4 Touch ENTER HEIGHT 30 0 MM 0 5 MM 5 MM OK 0 5 MM 5 MM ESC TEST 5 Touch 0 5 MM or 5 MM to increase the displayed plate height by this amou...

Page 114: ...VAL 25 0 MM is displayed displayed values may vary The current process parameter is shown on the lower left of the Touch Display EDIT PROCESS MY_OWN_PROG PLATE REMOVAL 25 0 MM ESC 2 To change the para...

Page 115: ...other parameters types by touching MORE CHANGES D2 Editing Number of Flow through Plates If COLLECT BOTH FRACTIONS or COLLECT NEG FRACTIONS was chosen as fraction of interest the flow through fractio...

Page 116: ...uld be edited go to SAVE PROCESS TO LIST described below in chapter 6 page 115 Saving the edited process Alternatively edit other parameters by touching MORE CHANGES Saving the edited process 1 Save t...

Page 117: ...ing operation Hazard of crushing fingers Operate only with attached protection screen Device must be able to be tilted backwards 3 Insert the MultiColumn Frame with up to twelve Multi 8 Columns Touch...

Page 118: ...5 MM 5 MM OK 0 5 MM 5 MM ESC TEST 7 Touch OK if the height was acceptable otherwise adapt plate height and retry the test Return to the previous sections such as C Selecting Plate Height page 99 or D...

Page 119: ...diately DO YOU WANT TO START THIS PROCESS NOW YES ESC NO 3 Touch YES to start the process Alternatively touch NO or ESC to go to the Welcome Screen Deleting a user defined process 1 To delete a proces...

Page 120: ...or until the desired process is displayed Touch the desired process name to select it The Process Management Screen appears MY_OWN_PROG VIEW EDIT DEL ESC 3 Touch DEL to proceed and confirm DO YOU WAN...

Page 121: ...MULTIMACS SEPARATOR BY MILTENYI BIOTEC 96 POS NEW 96 NEG POS SET UP 2 Touch SETUP for the Setup Screen PREFERENCES SERVICE TOOLS ESC 3 Touch PREFERENCES to display the Preference Category Screen SELE...

Page 122: ...Miltenyi Biotec before sending the MultiMACS M96 Separator back 1 Switch on the instrument then touch the Welcome Screen or wait for a few seconds until the Process Selection Screen appears WELCOME TO...

Page 123: ...MultiMACS Column Holder to move to the lock position SELECT PREF CATEGORY LOCK UNIT FOR TRANSPORT ESC MULTIMACS SEP IS READY FOR TRANSPORT SWITCH DEVICE OFF 6 As soon as the text above appears the in...

Page 124: ...hearing aids pacemakers measuring and control instruments computers and watches These items may be affected or damaged by the extremely powerful magnetic field The force of attraction between two magn...

Page 125: ...e to portrait orientation turn magnet counterclockwise by 90 Note that the notched corner marked red in figure 4 a b is now at the lower right For rotation of the magnet from portrait to landscape ori...

Page 126: ...cape to portrait orientation rotate Column Holder counter clockwise by 90 the same way as the MultiMACS 96 Magnet 2 For rotation of Column Holder from portrait to landscape orientation rotate Column H...

Page 127: ...126 6 Instructions for use Figure 5a Landscape orientation Figure 5b Portrait orientation...

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Page 129: ...merged in water or cleaned in a dish washer ultrasonic cleaner autoclave or similar appliances Clean up spills immediately Use a wash solution containing detergent e g 1 SDS solution and or 70 ethanol...

Page 130: ...129...

Page 131: ...f drops at the column tips move Tip Touch Plate so that the Multi 8 96 Columns move slightly in the MultiMACS Column Holder Control whether all drops at the column tips have been removed If drops are...

Page 132: ...t back the magnet to its former position Take out any objects causing the stop of the movement Subsequently press OK to restart the move In case there are no blocking objects visible touch RETRY If a...

Page 133: ...n the display when power is turned on Power cord or display cord is not plugged in Fuse is blown or missing Make sure power source matches power rating stamped on rear label Check fuse holder in rear...

Page 134: ...ialization of the system Column holder will be repositioned POSITION FAILED ERROR 111 INITIALIZING SYSTEM Incorrect positioning of the magnet Make sure device is not exposed to direct sunlight Touch O...

Page 135: ...M96 Separator at the power connector refer to figure 6 Detach the fuse holder with a sharp tool e g a screwdriver Remove the defect fuse and insert a new fuse with the type and rating 5 20 mm T2 5AH25...

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Page 137: ...sentative or Miltenyi Biotec Technical Support at Miltenyi Biotec headquarters Miltenyi Biotec B V Co KG Friedrich Ebert Stra e 68 51429 Bergisch Gladbach Germany Phone 49 2204 8306 830 Fax 49 2204 83...

Page 138: ...137...

Page 139: ...option the defective product so as to cause the same to operate in substantial conformance with said published specifications provided that you shall a promptly notify Miltenyi Biotec in writing upon...

Page 140: ...acements or corrections to the product or any component thereof as may be required to restore the full usability of your product If Miltenyi Biotec determines that a product for which you have request...

Page 141: ...BIOTEC HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES IN NO EVENT SHALL THE TOTAL LIABILITY OF MILTENYI BIOTEC HEREUNDER EXCEED THE GREATER OF 100 00 EUROS OR THE AMOUNT YOU ACTUALLY PAID FOR TH...

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Page 144: ...ervice Denmark Phone 80 20 3010 Customer service Norway Finland Iceland and Baltic countries Phone 46 46 280 72 80 Miltenyi Biotec Asia Pacific Pte Ltd Singapore Phone 65 6238 8183 macssg miltenyi com...