48
Product name: DOWFROST
™
Heat Transfer Fluid
Issue Date:
04/09/2015
Page 6 of 10
Acute dermal toxicity
Prolonged skin contact is unlikely to result in absorption of harmful amounts.
For the major component(s): Propylene glycol.
LD50, Rabbit, > 20,000 mg/kg
Acute inhalation toxicity
At room temperature, exposure to vapor is minimal due to low volatility. Mist may cause
irritation of upper respiratory tract (nose and throat).
For the major component(s):
LC50, Rat, 4 Hour, vapour, 6.15 mg/l No deaths occurred following exposure to a saturated
atmosphere.
Skin corrosion/irritation
Prolonged contact is essentially nonirritating to skin.
Repeated contact may cause flaking and softening of skin.
Serious eye damage/eye irritation
May cause slight temporary eye irritation.
Corneal injury is unlikely.
Sensitization
For the major component(s):
Did not cause allergic skin reactions when tested in humans.
For respiratory sensitization:
No relevant data found.
Specific Target Organ Systemic Toxicity (Single Exposure)
Evaluation of available data suggests that this material is not an STOT-SE toxicant.
Specific Target Organ Systemic Toxicity (Repeated Exposure)
In rare cases, repeated excessive exposure to propylene glycol may cause central nervous system
effects.
Carcinogenicity
Similar formulations did not cause cancer in laboratory animals.
Teratogenicity
For the major component(s): Did not cause birth defects or any other fetal effects in laboratory
animals.
Reproductive toxicity
For the major component(s): In animal studies, did not interfere with reproduction. In animal studies,
did not interfere with fertility.
Mutagenicity
In vitro genetic toxicity studies were negative. For the major component(s): Animal genetic toxicity
studies were negative.
Aspiration Hazard
