Waters ACQUITY UPLC, Overview And Maintenance Manual

Page 1: ...ACQUITY UPLC Quaternary Solvent Manager Overview and Maintenance Guide 715005050 Revision C Copyright Waters Corporation 2016 All rights reserved...

Page 2: ...ers Web site waters com Trademarks ACQUITY is a registered trademark of Waters Corporation ACQUITY UPLC is a registered trademark of Waters Corporation THE SCIENCE OF WHAT S POSSIBLE is a registered t...

Page 3: ...Street Milford MA 01757 USA Safety considerations Some reagents and samples used with Waters instruments and devices can pose chemical biological or radiological hazards or any combination thereof You...

Page 4: ...ance could void the user s authority to operate the equipment This device complies with Part 15 of the FCC Rules Operation is subject to the following two conditions 1 this device may not cause harmfu...

Page 5: ...nating current Electrical and electronic equipment with this symbol may contain hazardous substances and should not be disposed of as general waste For compliance with the Waste Electrical and Electro...

Page 6: ...y similar vary the location of the QC samples in the trays Ensure that QC sample results fall within an acceptable range and evaluate precision from day to day and run to run Data collected when QC sa...

Page 7: ...rized representative Address Waters Corporation Stamford Avenue Altrincham Road Wilmslow SK9 4AX UK Telephone 44 161 946 2400 Fax 44 161 946 2480 Contact Quality manager August 8 2016 715005050 Rev C...

Page 8: ...ing this device iv Applicable symbols v Audience and purpose v Intended use of the QSM vi Calibrating vi Quality control vi EMC considerations vi Canada spectrum management emissions notice vi ISM cla...

Page 9: ...and degasser vent tubing 25 2 3 Electricity source 28 2 3 1 Connecting to a wall electricity source 28 2 3 2 Connecting to a cart s electricity source 28 2 4 Connecting signal cables 29 2 4 1 Input ou...

Page 10: ...ling the i2Valve cartridge on the actuator 72 3 17 4 Installing the i2Valve actuator 76 3 18 Replacing the primary pump head s plunger and seals 79 3 18 1 Moving the plunger backward 80 3 18 2 Removin...

Page 11: ...133 A 7 Electrical symbols 135 A 8 Handling symbols 136 B Specifications 137 B 1 QSM and bioQSM physical specifications 137 B 2 QSM and bioQSM environmental specifications 137 B 3 QSM and bioQSM elec...

Page 12: ...n accuracy or precision A gradient proportioning valve GPV to dynamically blend solvents in any specified combination The GPV produces predictable gradient segments regardless of solvent compressibili...

Page 13: ...esulting in significant time savings 1 1 2 Auto Blend Plus Auto Blend Plus technology uses pure solvents and concentrated stocks to blend mobile phase compositions at a specific pH At the same time it...

Page 14: ...us of the module This LED is green when power is on and unlit when power is off Flow LED Indicates the flow status A steady green flow LED indicates that there is a flow through the solvent manager Do...

Page 15: ...the tubing that directs waste liquid to the waste container Solvent vent tubing Vents solvent to waste during priming Location of leak sensor The leak sensor continuously monitors the solvent manager...

Page 16: ...lvents upstream of the pumps i2Valve Electronically controlled ball check valve that allows flow in only one direction Primary pump Draws solvent transferring it to the accumulator pump and system as...

Page 17: ...cer APT which measures the pressure on the low pressure side of the degasser system is unaffected by altitude or barometric changes Table 1 1 Absolute pressure transducer attributes Item Absolute pres...

Page 18: ...tered solvents 4 The blended solvents flow through the i2Valve check valve and into the primary piston chamber 5 The primary piston delivers solvent to the accumulator the vent valve and the in line m...

Page 19: ...part number 715001307 Notice To avoid damaging solvent manager components do not use chloroform methylene chloride or toluene do not use ethyl acetate hexane or tetrahydrofuran THF without the hexane...

Page 20: ...ies with ferrules not previously assembled or set to tubing you must mark the compression screw and fitting body and ensure that the two marks line up when you tighten them Requirement Wear clean chem...

Page 21: ...th short flats and 2 piece stainless steel ferrule First use Short flats Compression screw 2 piece stainless steel ferrule Tighten the fitting finger tight plus an additional 3 4 turn using a 1 4 inch...

Page 22: ...ight plus as much as an additional 1 6 turn using a 1 4 inch open end wrench Re installed tightening 2 1 3 Stainless steel gold plated fitting with long flats and 2 piece stainless steel ferrule First...

Page 23: ...o prevent band spreading ensure that the tubing is fully bottomed in the fitting before tightening the compression screw First use tightening Re installed Long flats Compression screw 2 piece stainles...

Page 24: ...of lock ring with larger inside diameter ID Tighten the fitting finger tight 2 1 5 Short 1 4 28 fitting with flangeless ferrule and stainless steel lock ring installed on 1 16 inch OD tubing First us...

Page 25: ...finger tight 2 2 Installing and routing the waste and degasser vent tubing Notice To avoid contaminating system components wear clean chemical resistant powder free gloves when performing this proced...

Page 26: ...drain fitting located at the bottom of the solvent manager with methanol 2 Hold the back of the drain cup slide the waste tubing over the barbed drain fitting and route the tubing to a suitable waste...

Page 27: ...d false leak sensor alarms ensure proper drainage of waste Place the waste container below the system stack to permit gravity flow Ensure that the waste and degasser vent tubes do not crimp or bend A...

Page 28: ...rical shock observe these precautions Use SVT type power cord in the United States and HAR type power cord or better in Europe For requirements elsewhere contact your local Waters distributor Inspect...

Page 29: ...s electrical cables included in the startup kit to the receptacle on the rear panel of each system module 2 Connect the hooded male end of the cart s electrical cables to the power strips on its back...

Page 30: ...gnal cable to the connector Figure 2 4 Positive and negative lead connections Screw Connector Signal cable 3 Fit the grounding cable s fork terminal on the rear panel grounding stud and secure the ter...

Page 31: ...condition or hardware failure on another instrument or device for example beginning a gradient separation Stop flow Stops the flow from the solvent manager when it receives a contact closure input or...

Page 32: ...cal components and circuitry do not disconnect an electrical assembly while electrical power is applied to a module To completely interrupt power set the on off switch to the off position and then dis...

Page 33: ...te the plungers fill the tubing paths with solvent and flush away solvent and any precipitated salts that have been dragged past the plunger seals from the high pressure side of the piston chambers Pr...

Page 34: ...tems part number 715001307 on the ACQUITY UPLC System Bookshelf CD Required tools and materials Chemical resistant powder free gloves 30 mL syringe startup kit Seal wash solution Tubing adapter startu...

Page 35: ...e priming a dry solvent manager using a syringe shortens the time required for priming Recommendation Ensure that solvents which combine at the inlet manifold are fully miscible Notice To prevent salt...

Page 36: ...ath is primed Requirement Ensure that enough solvent remains in the solvent reservoirs to supply subsequent methods 2 7 2 Priming a dry solvent manager using a syringe Warning Observe Good Laboratory...

Page 37: ...nd retract the tubing lifting it away from the drip tray 4 Push the syringe plunger fully into the syringe barrel 5 Connect the tubing adapter to the syringe 6 Connect the syringe assembly to a short...

Page 38: ...gh solvent for future methods 2 8 Washing the plungers The plunger wash function washes the plungers with seal wash solvent It is designed to prevent the build up of precipitates on the pump plungers...

Page 39: ...garding the solvents you use Additionally consult the safety representative for your organization regarding its protocols for handling such materials Warning To avoid personal contamination with bioha...

Page 40: ...the leak and make the repairs necessary to stop it Notice To avoid damaging the leak sensor do not grasp it by the ribbon cable 5 Remove the leak sensor from its reservoir grasping the sensor by its...

Page 41: ...and its surrounding area 9 Align the leak sensor s T bar with the slot in the side of the leak sensor reservoir and slide the leak sensor into place Figure 2 14 Aligning T bar with slot T bar Slot in...

Page 42: ...or Leak sensor connector Leak sensor port on front of device 11 Power on the solvent manager 12 In the console select the solvent manager and then click Control Reset module to reset the solvent manag...

Page 43: ...Waters Web site includes phone numbers and e mail addresses for Waters locations worldwide Visit www waters com When you contact Waters be prepared to provide this information Error message if any Nat...

Page 44: ...Alternatives In the main window point to the visual representation of the system module that you want information about Obtain the serial number from the printed labels on the module s rear panel or...

Page 45: ...cartridge During scheduled routine maintenance or as necessary Replace the accumulator check valve During scheduled routine maintenance or as necessary Replace the pump head seals and plungers During...

Page 46: ...a particular component provide information about real time usage that can help you determine when to schedule routine maintenance for specific components You can specify usage thresholds and maintena...

Page 47: ...s materials Consult the Material Safety Data Sheets regarding the solvents you use Additionally consult the safety representative for your organization regarding its protocols for handling such materi...

Page 48: ...ubing to remove any air from the filter 6 Prime the solvent manager see Priming the solvent manager 3 9 Replacing the leak sensor Warning Observe Good Laboratory Practice GLP at all times particularly...

Page 49: ...hereafter before disconnecting an assembly 1 Power off the solvent manager 2 Open the solvent manager s door 3 Press down on the tab to detach the leak sensor connector from the front of the device Fi...

Page 50: ...tray 8 Connect the leak sensor connector to the front of the device Figure 3 6 Attaching leak sensor connector Leak sensor connector Leak sensor port on front of device 9 Power on the solvent manager...

Page 51: ...the inlet manifold 1 Power off the solvent manager 2 Open the solvent manager s door 3 Disconnect the finger tight outlet tubing fitting from the inlet manifold outlet Figure 3 7 Outlet tubing fitting...

Page 52: ...isconnect the inlet tubing fittings from the inlet manifold Figure 3 9 Inlet tubing fittings on manifold 1 Inlet tubing fitting 4 6 Remove the inlet manifold from the mounting bracket 7 Ensuring its g...

Page 53: ...ting 4 10 Reattach the outlet tubing fitting to the inlet manifold and tighten it with your fingers to the extent possible Requirement Ensure the outlet tubing is fully engaged by raising the inlet ma...

Page 54: ...Additionally consult the safety representative for your organization regarding its protocols for handling such materials Warning To avoid personal contamination from contact with biologically hazardou...

Page 55: ...hereafter before disconnecting an assembly 1 Power off the solvent manager 2 Open the solvent manager s door 3 Disconnect the four inlet manifold tubes from the GPV outlets Figure 3 14 GPV outlets 1 G...

Page 56: ...such materials Notice To avoid contaminating system components wear clean chemical resistant powder free gloves when performing this procedure Requirement Wear clean chemical resistant powder free gl...

Page 57: ...he 1 4 inch open end wrench tighten the fittings an additional 1 6 turn for existing fittings or 3 4 turn for new fittings 3 13 Installing or replacing the optional 250 L mixer filter Warning Observe...

Page 58: ...ect the outlet compression fitting by using the 1 4 inch open end wrench Figure 3 18 Location of outlet compression fitting 1 2 Mixer filter Outlet compression fitting 5 Using the 5 8 inch open end wr...

Page 59: ...clean chemical resistant powder free gloves when performing this procedure Requirement Wear clean chemical resistant powder free gloves when performing this procedure Required tools and materials Chem...

Page 60: ...e Avoid scratching the drive clamp or body Figure 3 21 Correct vent valve cartridge and drive clamp groove alignment Aligned grooves Vent valve cartridge housing Drive clamp 9 Insert the new vent valv...

Page 61: ...otice To avoid contaminating system components wear clean chemical resistant powder free gloves when performing this procedure Requirement Wear clean chemical resistant powder free gloves when perform...

Page 62: ...t selection valve cartridge 1 Hex screw 6 Remove the cartridge from the vent valve assembly by pulling straight forward 7 Unpack the replacement cartridge 8 Ensure that the groove in the cartridge hou...

Page 63: ...ex wrench to tighten it 11 Reattach all fittings and finger tighten them 12 Return the solvent bottles to their original location 13 Prime the solvent manager see Priming the solvent manager Requireme...

Page 64: ...lvent manager 3 Using the 5 16 inch open end wrench to hold the check valve in place disconnect the compression fitting by using the 1 4 inch open end wrench Figure 3 25 Compression fitting on check v...

Page 65: ...5 Unpack the new check valve 6 Ensure that the new PEEK washer is inserted into the new check valve so that its chamfered edge faces away from the check valve Figure 3 27 Accumulator check valve 1 2 3...

Page 66: ...Consult the Material Safety Data Sheets regarding the solvents you use Additionally consult the safety representative for your organization regarding its protocols for handling such materials Warning...

Page 67: ...ding its protocols for handling such materials Warning To avoid personal contamination from contact with biologically hazardous or toxic materials do not attempt to force or draw liquid or gas through...

Page 68: ...t manager Tip The solvent manager is referred to as pump on the warning label affixed to the i2Valve actuator 2 Open the solvent manager s door Notice To avoid damaging the connector or cable grasp th...

Page 69: ...ect the inlet manifold outlet tubing fitting on the side of the i2Valve and remove the tubing Figure 3 30 Inlet manifold outlet tubing fitting 1 2 3 Inlet manifold outlet tubing fitting Inlet manifold...

Page 70: ...her which is normally on the top face of the i2Valve cartridge does not remain in the pump head never place the actuator assembly or electrical connector in the drip tray 7 Remove the i2Valve actuator...

Page 71: ...g the i2Valve actuator do not attempt to force or draw liquid or gas through the valve s inlet or outlet ports Notice To avoid contaminating system components wear clean chemical resistant powder free...

Page 72: ...oid personal contamination from contact with biologically hazardous or toxic materials do not attempt to force or draw liquid or gas through the valve s inlet or outlet ports Notice To avoid damaging...

Page 73: ...endation Replace the cartridge whenever you replace the i2Valve actuator 4 Ensure that the PEEK washer is inserted into the cartridge so that its chamfered edge faces away from the cartridge Figure 3...

Page 74: ...r 1 2 Grooved end of cartridge i2Valve actuator 6 With one hand squeeze the 2 clamping plate tabs on the i2Valve actuator to hold the clamping plates against the cartridge Figure 3 36 i2Valve Clamping...

Page 75: ...below 8 Repeat the torquing pattern shown below at least three times gradually increasing the torque until the screws are uniformly tight Figure 3 37 Screw torquing pattern 1 2 3 4 Tip You can rotate...

Page 76: ...let ports Notice To avoid contaminating system components wear clean chemical resistant powder free gloves when performing this procedure Requirement Wear clean chemical resistant powder free gloves w...

Page 77: ...anifold outlet tubing fitting 1 2 3 Inlet manifold outlet tubing fitting Inlet manifold i2Valve 6 Reattach the outlet tubing fitting to the inlet manifold and tighten it with your fingers to the exten...

Page 78: ...to tighten the fitting an additional 1 6 turn for existing fittings or 3 4 turn for new fittings Figure 3 42 Inlet manifold outlet tubing fitting 1 2 3 Inlet manifold outlet tubing fitting Inlet manif...

Page 79: ...ood Laboratory Practice GLP at all times particularly when working with hazardous materials Consult the Material Safety Data Sheets regarding the solvents you use Additionally consult the safety repre...

Page 80: ...alling the pump head 10 Reinstalling the i2Valve actuator 11 Performing the solvent manager leak test see the console online Help Tip If the leak test results are unsatisfactory pressurize the seals t...

Page 81: ...nt Wear clean chemical resistant powder free gloves when performing this procedure Required tools and materials Chemical resistant powder free gloves 1 4 inch open end wrench 5 16 inch open end wrench...

Page 82: ...finger tight outlet tubing fitting on the inlet manifold outlet Figure 3 45 Outlet tubing fitting on manifold 1 2 Outlet tubing fitting Inlet manifold 5 Use the 1 4 inch open end wrench to disconnect...

Page 83: ...the shell nut 1 2 3 Pump head Shell nut i2Valve Notice To avoid damaging the i2Valve actuator assembly when removing it ensure that the PEEK washer which is normally on the top face of the i2Valve car...

Page 84: ...s for handling such materials Notice To avoid contaminating system components wear clean chemical resistant powder free gloves when performing this procedure Requirement Wear clean chemical resistant...

Page 85: ...2 Using a pliers remove the drip wire from the head assembly Figure 3 50 Removing drip wire 1 2 Drip wire Pliers 3 Using the 1 4 inch open end wrench disconnect the outlet tubing from the transducer F...

Page 86: ...accessible from the front of the pressure transducer Figure 3 53 Head bolts on primary pump head 1 Head bolts Notice To avoid damaging the plunger support the head from below as you remove it and do...

Page 87: ...ry Practice GLP at all times particularly when working with hazardous materials Consult the Material Safety Data Sheets regarding the solvents you use Additionally consult the safety representative fo...

Page 88: ...en removing head assembly components Bending or twisting the sapphire piston shaft can cause it to fracture or splinter 1 Use the recessed side of the plunger removal tool to apply pressure to both si...

Page 89: ...cal resistant powder free gloves when performing this procedure Requirement Wear clean chemical resistant powder free gloves when performing this procedure Required tools and materials Chemical resist...

Page 90: ...4 Remove the old seal wash seal from the seal wash housing and discard the old seal Figure 3 60 Location of seal wash seal Seal wash seal Seal wash housing 5 Using the smooth end of the seal removal t...

Page 91: ...to scratch any metal surfaces screw the threaded end of the seal removal tool into the plunger seal and carefully withdraw the seal from the pump head Figure 3 62 Removing plunger seal 1 2 Plunger se...

Page 92: ...aterials Notice To avoid contaminating system components wear clean chemical resistant powder free gloves when performing this procedure Requirement Wear clean chemical resistant powder free gloves wh...

Page 93: ...plunger seal with methanol and use the smooth end of the seal removal tool to place it in the pump head Figure 3 65 Placing plunger seal in pump head 1 2 3 4 Plunger seal Seal removal tool Seal remov...

Page 94: ...1 Plunger seal spacer 4 Orient the seal wash housing so that the holes on its side align with the holes on the side of the pump head and then guide it into place Figure 3 67 Installing seal wash housi...

Page 95: ...eal wash seal Seal wash housing 6 Place the support plate on top of the pump head ensuring that the round side of the plate is oriented toward the bottom side of the pump head Figure 3 69 Placing supp...

Page 96: ...s Consult the Material Safety Data Sheets regarding the solvents you use Additionally consult the safety representative for your organization regarding its protocols for handling such materials Notice...

Page 97: ...ls with methanol Figure 3 71 Pump head seals Pump head seals 2 Carefully insert the plunger shaft into the pump head until the shaft is no longer visible Requirement Ensure that the shaft does not mak...

Page 98: ...rforming this procedure Requirement Wear clean chemical resistant powder free gloves when performing this procedure Required tools and materials Chemical resistant powder free gloves 1 4 inch open end...

Page 99: ...Figure 3 73 Support plate bolts on primary pump head 1 Support plate bolts 3 Alternately tighten the head bolts so that they are uniformly torqued Figure 3 74 Head bolts on primary pump head 1 Head b...

Page 100: ...transducer cable in connector 1 2 Connector Tabs 6 Reattach the outlet tubing fitting to the transducer tighten it with your fingers to the extent possible and then use the 1 4 inch open end wrench to...

Page 101: ...vents you use Additionally consult the safety representative for your organization regarding its protocols for handling such materials Warning To avoid personal contamination from contact with biologi...

Page 102: ...xits from the left hand side 2 Insert the i2Valve assembly into the bottom of the primary pump head and route the cable behind the valve actuator 3 Tighten the shell nut using your fingers rotating th...

Page 103: ...the outlet tubing is fully engaged by raising the inlet manifold while attaching the outlet tubing fitting Figure 3 81 Reattaching outlet tubing fitting 1 2 Outlet tubing fitting Inlet manifold 7 Tig...

Page 104: ...or with the white arrow on the receptacle in the 12 o clock position and insert the connector into the receptacle Figure 3 83 Inserting i2Valve connector into receptacle 1 2 3 i2Valve connector Connec...

Page 105: ...ves when performing this procedure Requirement Wear clean chemical resistant powder free gloves when performing this procedure Required tools and materials Chemical resistant powder free gloves 1 4 in...

Page 106: ...nt to move backward 4 Click Move Backward and then wait for the plunger to stop 3 19 2 Removing the accumulator pump head Warning Observe Good Laboratory Practice GLP at all times particularly when wo...

Page 107: ...ng as close to the pump head as possible Figure 3 84 Location of seal wash tubing Seal wash tubing Seal wash tubing 2 Using the pliers remove the drip wire from the head assembly Figure 3 85 Removing...

Page 108: ...he tubing connection from the check valve using the 1 4 inch open end wrench Figure 3 87 Location of check valve tubing connection Check valve Place 5 16 inch open end wrench here Place 1 4 inch open...

Page 109: ...bolts on accumulator pump head 1 Head bolts Notice To avoid damaging the plunger support the head from below as you remove it and do not tilt the head when withdrawing it 7 Using the T27 TORX driver l...

Page 110: ...lunger Warning Observe Good Laboratory Practice GLP at all times particularly when working with hazardous materials Consult the Material Safety Data Sheets regarding the solvents you use Additionally...

Page 111: ...hand lacerations from sharp edged surfaces use care when removing head assembly components Bending or twisting the sapphire piston shaft can cause it to fracture or splinter 1 Use the recessed side of...

Page 112: ...ts wear clean chemical resistant powder free gloves when performing this procedure Requirement Wear clean chemical resistant powder free gloves when performing this procedure Required tools and materi...

Page 113: ...Remove the old seal wash seal from the seal wash housing and discard the old seal Figure 3 96 Location of seal wash seal Seal wash seal Seal wash housing 5 Using the smooth end of the seal removal to...

Page 114: ...to scratch any metal surfaces screw the threaded end of the seal removal tool into the plunger seal and carefully withdraw the seal from the pump head Figure 3 98 Removing plunger seal 1 2 Plunger sea...

Page 115: ...materials Notice To avoid contaminating system components wear clean chemical resistant powder free gloves when performing this procedure Requirement Wear clean chemical resistant powder free gloves w...

Page 116: ...plunger seal with methanol and use the smooth end of the seal removal tool to place it in the pump head Figure 3 101 Placing plunger seal in pump head 1 2 3 4 Plunger seal Seal removal tool Seal remov...

Page 117: ...Plunger seal spacer 4 Orient the seal wash housing so that the holes on its side align with the holes on the side of the pump head and then guide it into place Figure 3 103 Installing seal wash housi...

Page 118: ...al wash seal Seal wash housing 6 Place the support plate on top of the pump head ensuring that the round side of the plate is oriented toward the bottom side of the pump head Figure 3 105 Placing supp...

Page 119: ...ls Consult the Material Safety Data Sheets regarding the solvents you use Additionally consult the safety representative for your organization regarding its protocols for handling such materials Notic...

Page 120: ...s with methanol Figure 3 107 Pump head seals Pump head seals 2 Carefully insert the plunger shaft into the pump head until the shaft is no longer visible Requirement Ensure that the shaft does not mak...

Page 121: ...rocedure Requirement Wear clean chemical resistant powder free gloves when performing this procedure Required tools and materials Chemical resistant powder free gloves 1 4 inch open end wrench 5 16 in...

Page 122: ...e 3 109 Support plate bolts on accumulator pump head 1 Support plate bolts 3 Alternately tighten the head bolts so that they are uniformly torqued Figure 3 110 Head bolts on accumulator pump head 1 He...

Page 123: ...le to the bulkhead Figure 3 112 Pressure transducer cable in connector 1 2 Connector Tabs 6 Using the 5 16 inch open end wrench to hold the check valve cartridge in place reconnect the tubing connecti...

Page 124: ...ransducer tighten it with your fingers to the extent possible and then use the 1 4 inch open end wrench to tighten the fitting an additional 1 6 turn for existing fittings or 3 4 turn for new fittings...

Page 125: ...instrument or device Do not spray or otherwise apply water directly onto any equipment surface Warning To avoid personal injury use eye and hand protection during the cleaning process Requirement Use...

Page 126: ...or property damage resulting from the failure of individuals to comply with any safety precaution when installing repairing or operating any of its instruments or devices The following symbols warn of...

Page 127: ...nts and devices fitted with nonmetallic tubing Warning To avoid injury from bursting nonmetallic tubing heed these precautions when working in the vicinity of such tubing when it is pressurized Wear e...

Page 128: ...an process biohazards corrosive materials or toxic materials Warning To avoid personal contamination with biohazards toxic materials or corrosive materials you must understand the hazards associated w...

Page 129: ...ges or modifications to this unit not expressly approved by the party responsible for compliance could void the user s authority to operate the equipment Avertissement Toute modification sur cette uni...

Page 130: ...f the tubing Avertissement Manipulez les tubes en polym re sous pression avec precaution Portez syst matiquement des lunettes de protection lorsque vous vous trouvez proximit de tubes en polym re pres...

Page 131: ...ostante Non utilizzare tubi eccessivamente logorati o piegati Non utilizzare tubi non metallici con tetraidrofurano THF o acido solforico o nitrico concentrati Tenere presente che il cloruro di metile...

Page 132: ...THF Methylene chloride Dimethyl sulfoxide THF This warning applies to Waters instruments fitted with nonmetallic tubing This warning applies to instruments operated with flammable solvents August 8 2...

Page 133: ...recchiatura secondo modalit non previste dal produttore pu compromettere la protezione offerta dall apparecchiatura Advertencia el usuario deber saber que si el equipo se utiliza de forma distinta a l...

Page 134: ...on does not appear on the instrument or device Warning To protect against fire replace fuses with those of the type and rating indicated in the Replacing fuses section of the Maintenance Procedures ch...

Page 135: ...trument manuals and on an instrument s front or rear panels Symbol Description Electrical power on Electrical power off Standby Direct current Alternating current Alternating current 3 phase Safety gr...

Page 136: ...can appear on labels affixed to the packaging in which instruments devices and component parts are shipped Symbol Description Keep upright Keep dry Fragile Use no hooks Upper limit of temperature Lowe...

Page 137: ...in with 2 2 cm 0 875 in feet Width 34 3 cm 13 5 in Depth 66 1 cm 26 0 in Weight 27 5 kg 60 5 lb B 2 QSM and bioQSM environmental specifications Attribute Specification Acoustic noise 65 dBA system Am...

Page 138: ...eir electrical power from a local level such as an electrical wall outlet c Pollution Degree 2 A measure of pollution on electrical circuits that can produce a reduction of dielectric strength or surf...

Page 139: ...solvent A with i2Valve Back pressure 4137 to 6895 kPa 41 to 69 bar 600 to 1000 psi with degassed water Flow precision 0 075 RSD or 0 020 min SD whichever is greater based on six replicates i2Valve Tes...

Page 140: ...5 C 0 3 C Detector UV 254 nm wavelength Compressibility compensation Automatic and continuous Priming Wet priming can run at flow rates up to 4 mL min Pump seal wash Equipped with a wash system to flu...

Page 141: ...tainless steel DLC fluoroelastomer fluoropolymer Nitronic 60 PEEK PEEK blend PPS ruby sapphire titanium alloy UHMWPE blend zirconia bioQSM DLC fluoroelastomer fluoropolymer Nitronic 60 PEEK PEEK blend...