Bruker AVANCE, User Manual

Page 1: ...AVANCE Site Planning for AVANCE Systems 400 700 MHz with Ascend Aeon actively refrigerated Magnets User Manual Version 008 Innovation with Integrity NMR ...

Page 2: ...red trademarks of their re spective holders This manual was written by Daniel Baumann and Stanley J Niles January 13 2017 Bruker Corporation Document Number 10000055449 P N H157655 For further technical assistance for this product please do not hesitate to contact your nearest BRUKER dealer or contact us directly at Bruker Corporation am Silberstreifen 76287 Rheinstetten Germany Phone 49 721 5161 ...

Page 3: ...17 2 8 Emergency Planning 17 2 8 1 Fire Department Notification 18 3 System Components 19 3 1 Superconducting Magnet Components 19 3 2 Console and Other System Components 20 3 3 CryoProbe System Optional 21 3 4 CryoProbe Prodigy System Optional 22 3 5 Other Optional Components 23 4 Magnet Access and Rigging 25 4 1 Considerations for Off loading on Site 25 4 2 Considerations for Transport to the NM...

Page 4: ...e 53 7 3 2 3 Reducing DC Interference 53 7 3 3 AC EMF Interference 54 7 3 3 1 Measuring AC EMF Interferences 54 7 3 3 2 Guidelines for AC EMF Interference 54 7 3 3 3 Reducing AC EMF Interference 55 7 3 4 HF Interference 55 7 3 4 1 Measuring HF Fluctuating Fields 55 7 3 4 2 Most Commonly Studied Nuclei 56 7 3 4 3 Guidelines for HF Interference 56 7 3 4 4 Reducing HF Interference 56 8 Utility Requir...

Page 5: ...essor Indoor Air Cooled 88 10 2 1 3 Helium Compressor Outdoor Air Cooled 88 10 2 2 Space Requirements and Specifications 89 10 2 2 1 Indoor Helium Compressors 89 10 2 2 2 Outdoor Helium Compressors 90 10 3 Helium Cylinders 91 10 4 Summary of CryoProbe Options 91 10 5 CryoProbe Prodigy System Optional 93 10 6 CryoFit 95 10 6 1 Introduction 95 10 6 2 Installation Requirements 95 11 Installation 97 1...

Page 6: ...Contents vi H157655_1_008 ...

Page 7: ... fact is 1 mT 10 G Likewise the unit kilowatt is used for the measure of heat energy e g amount of heat generated by a device per hour Some readers may be more familiar with these measurements in BTU hour For comparison the conversion factor is 1 BTU hour 0 000293 kW BTU British Thermal Unit which is the required heat to raise 1 pound of H2O by 1 degree Fahrenheit Wherever possible both the metric...

Page 8: ...K K C 273 15 K C C K 273 15 F K K F 459 67 1 8 K F F K 1 8 459 67 Magnet Field Strength Tesla T Gauss G 1 T 104 G Heat Energy BTU hour kW 1 BTU hour 0 000293 kW BTU British Thermal Unit which is the required heat to raise 1 pound of H20 by 1 degree Fahrenheit SI International System of Units Table 1 1 Metric to American Conversion Factors ...

Page 9: ...s are fitted with shock and tilt watches during transportation Only certified operators of fork lifts pallet jacks and cranes should handle the transport and rigging Crates should not be left outside but should be brought inside immediately to protect equipment Storage conditions Temperature 5 40 C Humidity 50 at 23 C 2 2 The Magnetic Field Since the magnetic field of the magnet system is three di...

Page 10: ... ramped to field Human experience and reaction speed are totally inadequate to cope with the extremely nonlinear forces the magnet exerts on iron objects Therefore no ferromagnetic objects should be allowed to enter the magnet room after the magnet is energized 2 2 1 Exclusion Zone The Exclusion Zone is the area inside the magnet s 5 Gauss 0 5 mT field line extended in all directions including roo...

Page 11: ...llator starts working normally again Newer pacemakers switch into special mode at 1 mT older models already at 0 5 mT 5 Gauss Source www supermagnete ch Pregnant Workers There are no special guidelines concerning magnetic fields that we are aware of for pregnant workers when compared to all other people Pregnant workers are mentioned in Section E of the Annex to the EMF Directive European Communit...

Page 12: ...s containing ferromagnetic materials and injuries due to flying ferromagnetic objects and these considerations can lead to much lower restriction levels such as 0 5 mT IEC 2002 The exposure limits to be set with regard to these non biological effects are not however the duty of ICNIRP From ICNIRP Guidelines published 2009 http www icnirp de documents statgdl pdf European Community Directive The Eu...

Page 13: ...rkplace applicable under special conditions to selected subgroups of people according to BGV B11 Table 2 2 BGV B11 Standards Under Special Conditions for Selected Subgroups The next table shows the maximum retention periods within different stray field regions below 5 Tesla for standard precautionary situations The corresponding spatial regions within and around the super conducting magnet can be ...

Page 14: ...he room becomes pressurized by helium gas during a magnet quench Room layout ceiling clearance and magnet height must be such that an easy transfer of liquid nitrogen and helium is possible This will considerably reduce the risk of accidents 2 3 1 Regular Ventilation Regular HVAC systems should be able to handle 3 5 room air exchanges per hour and provide temperature stability of 1 C per 24 hours ...

Page 15: ...ve boiling temperature As a result a fraction of the liquid constantly evaporates into the gas phase leading to a pressure build up inside the storage dewar A very important characteristic of cryogens is their enormous increase in volume during the conversion from liquid to gaseous phase This conversion follows a raise in gas temperature starting at the boiling temperatures of the cryogenic liquid...

Page 16: ...cured to a wall or structural column well outside the 5 Gauss line to prevent a dangerous accident A He gas purity of 4 6 99 996 is recommended With the Aeon magnet helium fills are typically needed only during the magnet installation Helium refills are not required during the normal operation given that there is no helium loss Helium top offs or refills are to be done by Bruker engineers these ar...

Page 17: ... Safety Regulations In addition to the above safety precautions any country specific safety regulations for operating NMR systems must be fulfilled These may include for example regulations on Facilities of a controlled access area around the magnet Working conditions at computer stations Use of anesthesia gases Handling of laboratory and transgenic animals 2 8 Emergency Planning Due to the strong...

Page 18: ... can be invaluable in creating an Emergency plan In a NMR laboratory use only non magnetic fire extinguishers Breathing equipment which uses oxygen tanks made out of magnetic material can be life threatening when used close to a magnet system which is energized During a quench helium gas escaping from the system must not be mistaken for smoke Instruct the fire department and technical service not ...

Page 19: ...sed in a sub cooled liquid helium 2 K bath An additional liquid helium bath operating at a standard temperature of 4 2 K is located above the sub cooled helium section and is also housed in the outer vacuum enclosure After the initial charging with electrical current the magnet runs in persistent mode The current runs in a closed loop inside the system and the magnet itself is no longer connected ...

Page 20: ...itation signals from the console amplifiers to the probe and the NMR signal back from the sample to the receiver 3 The HPPR 2 amplifies filters and routes the NMR response signals from the probe to the RX22 receiver It switches the RF transmitter output to the probe 4 The BCU II Unit delivers very cold gas either nitrogen or dry air through a flexible isolated non magnetic transfer line It is poss...

Page 21: ...cooler a cryocontroller a vacuum system and He transfer lines The unit cools compressed helium gas by expansion and provides and maintains the vacuum insulation The unit also supervises all CryoProbe operations 3 The research grade Helium gas cylinder provides research grade helium gas 99 9999 at high pressure min 200 bar for flushing the probe prior to a cool down cycle The cylinder includes a re...

Page 22: ...robe the broadband CryoProbe Prodigy uses nitrogen cooled RF coils and preamplifiers to deliver a sensitivity enhancement over room temperature RT probes of a factor of 2 to 3 for X nuclei from 15 N to 31 P The Prodigy package is comprised of the probe a control unit PCU and a liquid nitrogen vessel thus siting is easy and no additional infrastructure is required Figure 3 3 CryoProbe Prodigy with ...

Page 23: ...demand for simplicity versatility and higher throughput in NMR sample tube automation 3 SampleXpress allows automatic measurement of NMR samples with Bruker NMR spectrometers SampleXpress is controlled by TopSpin or IconNMR and is equipped with integrated barcode reader registration which is under control of SampleTrack 4 The imaging accessory cabinet houses the gradient amplifiers for micro imagi...

Page 24: ...System Components 24 H157655_1_008 ...

Page 25: ...em crates The elevation of the loading dock relative to the laboratory will determine if a crane is required or if an elevator is needed for the transportation of the magnet from the loading dock to the laboratory The load bearing capacity of the loading dock must be sufficient for the system Refer to the transport weights of the magnet system console and accessories listed in the chapter If heigh...

Page 26: ...factor if for example corners must be navigated It is important to make sure the rigging equipment for magnet assembly e g a long I beam for the gantry can be brought into the lab The console and magnet must be moved in an upright position Refer to the section Rigging Equipment 31 for more information 4 3 Transport Dimensions and Weights 4 3 1 Magnet Transport Dimensions Door Dimensions for Magnet...

Page 27: ...add as much as 9 cm to the transport height Table 4 2 Door Dimensions Wide Bore 89 mm 4 3 2 Magnet Stand Transport Dimensions Door Dimensions for Magnet Stand Accessories Access Accessories Crate Size including stand if applicable m Magnet Stand L D H 400 54 Ascend Aeon F85 570 ADI 0 97 0 76 1 20 400 54 Ascend Aeon F85 700 ADI 0 97 0 76 1 20 400 54 Ascend Aeon F85 570 API 0 97 0 76 1 20 400 54 Asc...

Page 28: ...gnet Type Magnet Weight with Crate kg Magnet Weight w o Crate Stand kg 400 54 Ascend Aeon 600 490 500 54 Ascend Aeon 700 590 600 54 Ascend Aeon 1000 850 700 54 Ascend Aeon 1300 1150 The weights of the accessories are approximations The actual weight may vary depending on the options and accessories that are ordered Table 4 5 Magnet Transport Weights Standard Bore 54 mm Magnet Type Magnet Weight wi...

Page 29: ...2 1 53 210 1 02 0 71 1 66 AVANCE NanoBay 1 34 0 75 1 04 120 without pallet and packing material 0 77 0 45 0 93 Note The pallet is now integrated into the crate Weights include pallets and packing material as required Weights are for a standard AVANCETM configuration actual weights may increase depending on options selected Transport width width indicated minimum 1 cm clearance on each side These a...

Page 30: ...0 58 0 42 0 57 74 CryoProbe shipped in a CryoCase on a pallet 1 20 0 80 0 68 60 CryoCooling Unit 1 66 0 95 0 68 400 CryoProbe System He Compressor Indoor Water cooled 0 94 0 84 1 18 120 CryoProbe System He Compressor Indoor Air cooled packed in three cartons on one pallet 0 69 0 69 1 12 140 CryoProbe System He Compressor Outdoor Air cooled packed in three cartons on one pallet 0 55 0 55 0 90 140 C...

Page 31: ...n NMR magnet system Pallet Jack and or Fork Lift For transporting system magnet and accessories to the laboratory A Frame or Lifting Hook An A Frame or lifting hook may be used inside the laboratory during assembly phase When a lifting hook is used the hook capacity must be certified to hold the required weight of the magnet before installation Figure 4 1 A Frame Gantry for Lifting the Magnet Insi...

Page 32: ...Magnet Access and Rigging 32 H157655_1_008 ...

Page 33: ...ng system being used to lift the magnet during the assembly phase of the installation If a transverse I beam is used in conjunction with the lifting system this must fit within the confines of the soffit In lieu of a lifting system a fixed lifting hook capable of supporting the magnet at a sufficient height can be used to assemble the magnet However this option is usually not ideal See notes below...

Page 34: ...H157655_1_008 5 1 Helium Transfer Line Figure 5 1 Ceiling Height Requirements 1 Ceiling height must allow for insertion of helium transfer lines 2 Liquid helium dewar 3 Ceiling height requirements must be met over this area 4 Magnet ...

Page 35: ...mm Z mm V mm W mm Remarks Ascend 53962 1455 1508 2060 708 655 D3XX 29085 1455 1508 2060 433 380 Reduced Height 29515 1455 1508 1250 503 450 Reduced Height Note When using soffits sufficient space must be left for the required transfer line length The magnet may need to be placed off center within the soffit as opposed to being centered Table 5 1 Helium Transfer Line Dimensions ...

Page 36: ...the ceiling height requirements in the ceiling height requirements table were either calculated and or their meaning Note that the values were calculated for the smallest available magnet stand Minimum Operational Ceiling Height Helium Transfer Line 29085 The minimum operational ceiling height using the helium transfer line 29085 is calculated by adding the height of the shim upper part that has t...

Page 37: ...model and stand Magnet Type Special LHE Transfer Line for Reduced Ceiling Height m Standard LHE Transfer Line m 400 54 Ascend Aeon 2 66 3 04 500 54 Ascend Aeon 2 66 3 04 600 54 Ascend Aeon 3 00 3 39 700 54 Ascend Aeon 3 00 3 39 Table 5 2 Minimum Ceiling Height Requirements Standard Bore 54 mm Magnet Type Special LHE Transfer Line for Reduced Ceiling Height m Standard LHE Transfer Line m 400 89 Asc...

Page 38: ...Ceiling Height Requirements 38 H157655_1_008 ...

Page 39: ... may remain within this area 5 mT 50 G Magnet power supply RF power amplifier Cryo cooling platform Electrical transformers which are a component of many electrical devices may become magnetically saturated in fields above 50 Gauss 5 mT The safety characteristics of equipment may also be affected 2 mT 20 G Magnetic storage material The information stored on tapes may be destroyed or corrupted 1 mT...

Page 40: ...0 54 Ascend Aeon 0 49 0 52 0 65 0 80 1 10 1 42 1 87 Distances are measured in radial direction from magnetic center Table 6 2 Horizontal Stray Fields Standard Bore 54 mm Magnet Type 5 0 mT 50 G 3 0 mT 30 G 1 0 mT 10 G 0 5 mT 5 G 0 2 mT 2 G 0 1 mT 1 G 0 05 mT 0 5 G 400 89 Ascend Aeon 0 44 0 47 0 55 0 60 0 69 0 82 1 03 500 89 Ascend Aeon 0 50 0 54 0 62 0 70 0 92 1 17 1 52 600 89 Ascend Aeon 0 60 0 6...

Page 41: ... 1 60 2 01 2 42 2 95 Distances are measured in axial direction from magnetic center Table 6 4 Vertical Stray Fields Standard Bore 54 mm Magnet Type 5 0 mT 50 G 3 0 mT 30 G 1 0 mT 10 G 0 5 mT 5 G 0 2 mT 2 G 0 1 mT 1 G 0 05 mT 0 5 G 400 89 Ascend Aeon 0 79 0 86 1 05 1 20 1 45 1 70 2 02 500 89 Ascend Aeon 0 88 0 97 1 21 1 40 1 73 2 07 2 49 600 89 Ascend Aeon 1 02 1 12 1 38 1 60 1 97 2 34 2 81 700 89 ...

Page 42: ...Magnetic Stray Fields 42 H157655_1_008 6 3 Stray Field Plots Figure 6 1 Example of a Stray Field Plot ...

Page 43: ... power lines transformers radio TV stations and other possible RF sources 7 1 Vibrations External vibrations may cause field modulations in the sample cavity This could result in vibration sidebands matched NMR signals that appear on either side of a main signal peak The effect of vibrations on NMR performance will depend on the type of work being carried out the type of system and the site buildi...

Page 44: ...ed Isolator Options All Bruker magnets are delivered standard with integrated isolators as follows EMI Elastomeric Isolators Standard for 300 500 MHz magnets ADI Air Spring and Damped Isolators Standard for 600 MHz magnets optional for 300 500 MHz magnets API Air Piston Isolators Standard for 700 800 MHz magnets optional for 300 600 MHz magnets 7 1 2 General Vibration Guidelines General guidelines...

Page 45: ...ing many electron microscopes SEMs and TEMs and E Beam systems VC E 3 12 125 A challenging criterion to achieve Assumed to be adequate for the most demanding of sensitive systems including long path laser based small target systems E Beam lithography systems working at nanometer scales and other systems requiring extraordinary dynamic stability VC F 1 56 62 5 Appropriate for extremely quiet resear...

Page 46: ...f to 0 125 Hz enabling the collection of correct amplitudes in the low frequency range Also we recommend simultaneous measurements multiple transducers along the 3 axis vertical 2 horizontal 7 1 4 Bruker NMR Floor Vibration Guidelines EMI damping system Elastomeric Isolators Figure 7 2 Threshold Values of Floor Acceleration Tolerance Level for EMI Dampers Frequency Maximum Velocity in Vertical Dir...

Page 47: ...ite Survey Measurement H157655_1_008 47 Figure 7 3 Example of the Bruker Tolerance Level for Elastomer Dampers Resolution 0 125 Hz 1 200 Hz 30 min Average Measurement 1 displayed in velocity Figure 7 4 Elastomer Dampers ...

Page 48: ...cal damping Frequency Maximum Velocity in Vertical Direction Maximum Velocity in Horizontal Direction 1 5 Hz 3 µm s 1 6 µm s 5 20 Hz 3 12 µm s 1 6 6 4 µms 20 Hz 12 µm s 6 4 µm s Table 7 3 ADI Damping System Elastomeric Isolators Figure 7 5 Example of the Bruker Tolerance Level for ADI Dampers Resolution 0 125 Hz 1 200 Hz 30 min Average Measurement 1 displayed in velocity ...

Page 49: ...nment and Site Survey Measurement H157655_1_008 49 Figure 7 6 ADI Dampers 7 1 6 Floor Vibration Guidelines Bruker Nano C API Damping System API Damping System Figure 7 7 Tolerance Level Nano C for API Dampers ...

Page 50: ...25 Hz 1 200 Hz 30 min Average Spectra Measurement 1 displayed in velocity According to VDI 2038 2013 Bruker is following the threshold values of sensitive laboratory equipment Bruker implemented a Nano C limit which is less critical as Nano D The only big difference in observing these data is to use a higher resolution as only 1 3 octave We recommend to measure with a resolution of 0 125 Hz to get...

Page 51: ...mendations represent a situation that may not be achievable Please consult with Bruker for possible solutions if one or more of these recommendations cannot be satisfied Object Minimum distance from magnetic center m Steel reinforced walls 2 Radiators plumbing pipes 2 Metal table metal door 2 5 Filing cabinet steel cabinet 2 5 Iron or steel beams 3 Massive objects e g boiler 3 Table 7 5 Guidelines...

Page 52: ...en you should contact Bruker BioSpin for a site survey Bruker offers a service for measuring EMF interferences using specialized hardware and software We recommend measurements to be done over a period of at least one hour ideally much longer to try capturing both steady state conditions and transient events However often there is a need to do much longer measurements including overnight 7 3 1 Typ...

Page 53: ...s The recorded waveform is processed in different ways 7 3 2 2 Guidelines for DC Interference When determining the effect of fluctuating magnetic fields two parameters are important the size of the fluctuation and the rate of change as follows In a moving window of 1000 seconds the difference of the maximum and minimum values from the filtered and sub sampled data set should not exceed B Bmax Bmin...

Page 54: ...block wise 4 seconds processed digital LP filter with fc 225 Hz subsampled to 500 S s FFT 200 Hz band width and 0 25 Hz resolution The single block magnitude spectra are used to compute average and peak hold spectra as well as spectrograms waterfall plots reflecting the evolution of AC EMF spectral content over time Measurements should be performed when possible sources are in operation Typically ...

Page 55: ... Interference The NMR instrument is effectively a very sensitive radio frequency receiver Possible sources of interference are local radio or television broadcasts low Earth orbit satellite systems and signals emitted by personal paging systems Of particular concern will be interference at frequencies at which NMR experiments are carried out Although the interference effects will depend greatly on...

Page 56: ...rference Screening a site for possible HF Interference is complicated and expensive Shielding of the laboratory with a Faraday cage is a possible solution though having to take such measures is quite rare When designing and manufacturing the Bruker spectrometers care is taken to provide adequate shielding and the instruments rarely suffer from interference in normal HF environments Furthermore the...

Page 57: ...quirement Considerations For installation of the AVANCE system a 230V 16A outlet is needed for the turbo pumps as well as an additional 230V 16A outlet for the magnet power supply during installation and service A TwoBay with Solid Accessory 600 700 MHz can be approximated to a standard TwoBay plus High Power cabinet and so the total power requirements is 5 kW The power requirements for the CP MAS...

Page 58: ...0 Hz 30A single phase in USA 2 4 Bayvoltex Chiller for MicroImaging Systems 230V 50 60 Hz 16A single phase or 208V 60 Hz 20A single phase in USA approx 0 45 kW BCU I BCU II 230V 50 60 Hz 16A single phase or 208V 60 Hz 20A single phase in USA power for BCU II must come from separate outlet 0 45 kW BCU I 2 3 kW BCU II UPS for CCU UPS requirements At least 5 kW for the AVANCE and CCU UPS for AVANCE S...

Page 59: ...point of 51 C 60 F for the compressed gas Compressed air or nitrogen gas for spinning Compressed air or nitrogen gas for sample ejection and for the magnet s vibration isolation units Compressed air or nitrogen gas for the optional CryoProbe system 8 3 2 Gas Supply The gas supply used depends on the frequency of the system 400 MHz Compressed air 500 MHz Nitrogen gas with 95 purity 600 800 MHz Nitr...

Page 60: ...her i e 3 cfm It is recommended to use a dual unit oil less air compressor rated at minimum double capacity of the specified requirement Please refer to the next section on air compressors Table 8 2 Pressure and Flow Requirements 8 3 3 Other Specifications Oil Content Purity ISO 8573 1 2010 1 1 0 oil free Water Content For the BCU I cooling unit the compressed gas should have a dew point of 51 C 6...

Page 61: ...supply line Buffer containers must meet the appropriate safety requirements They must have a working pressure of 16 bar and be proofed up to 30 bar Use tanks which are internally coated with water and acid resistant material This will prevent corrosion from impurities such as SO2 The three major components in a suitable compressed air supply line include the compressor dryer and appropriate filter...

Page 62: ...nt the pressure loss along the line between the compressor and the final gate valve The pressure drop depends on the pipe diameters An internal diameter of 8 mm has been found to be suitable The plastic tubing used to carry the supply from the final gate valve to the console has an outside diameter of 8 mm and is supplied by Bruker Some types of dryers e g absorption dryers can use up to 25 of the...

Page 63: ... sieves are normally used alternatively A portion of the dry air output of sieve A is fed into sieve B to regenerate it The amount used in regeneration is typically 15 but up to 25 may be required for very low dew points The process is automatically reversed at regular intervals with the output of sieve B used to regenerate sieve A Advantages Much lower dew points are achievable compared to refrig...

Page 64: ...eved by using either a refrigerated indoor or outdoor chiller or a water water heat exchanger depending on the specific conditions and utilities available at the customer site It is strongly recommended to provide emergency backup cooling water to the helium compressor in case of failure of the main cooling water source A secondary chiller or and domestic city water may be used as emergency backup...

Page 65: ...on Air Conditioning Constant air pressure temperature and humidity is crucial for high performance operation Ideally an absolute room temperature of between 17 25 C should be kept Room should not fluctuate more than 1 C per 24 hours for 300 500 MHz systems and 0 5 C per 24 hours for 600 MHz and above near the magnet or cabinets Even with small changes within this narrow range it is essential that ...

Page 66: ... parts to avoid condensation at the location of cold parts With a laboratory temperature of 17 C the humidity can rise up to 67 7 and with 25 C it will be only 41 4 Temperature in the NMR laboratory Maximum humidity for a dew point of 11 C 12 C 13 C 14 C 15 C 16 C 17 C 67 7 72 4 77 3 82 5 88 0 93 8 18 C 63 6 68 0 72 6 77 5 82 6 88 1 19 C 59 7 63 8 68 2 72 8 77 6 82 7 20 C 56 1 60 0 64 1 68 4 72 9 ...

Page 67: ...CryoProbe outdoor air cooled 8 5 kW He Compressor BNL inside water cooled 2 0 kW He Compressor BNL outside air cooled 2 2 kW Table 8 5 Heat Dissipation into the Room by Typical AVANCE Systems 8 6 2 System Stability Air Temperature The heat dissipation of the magnet system is constant over time It is essential to minimize or avoid short term oscillations of the HVAC system and provide a continuous ...

Page 68: ...9 5 134 75 500 89 Ascend Aeon 262 5 131 25 600 89 Ascend Aeon 225 4 112 7 700 89 Ascend Aeon 236 6 118 3 Table 8 7 Total Gas Volume and Maximum He Gas Flow Wide Bore 89 mm Regarding the emergency gas exhaust important considerations include but are not limited to the following Amount of liquid helium Taking the 750 WB US2 magnet as an example the total amount of liquid helium is 473 liters In case...

Page 69: ...o it turns on automatically when the O2 level drops below the safety set point It should be installed in addition to a manual switch Measures should be taken to prevent it from being turned on during a fire Quench Pipes This solution may be needed as a last resort solution when the laboratory is small and any of the other options are not sufficient to ensure safety after a magnet quench This solut...

Page 70: ...important to understand that the soffit will be the first area to fill up with helium gas during a quench or during a helium fill It is important to elicit extra caution in this case A passive louver or an exhaust duct with fan are practical solutions when soffits are used This will prolong the cycle of the magnet between rebuilds by preventing helium gas build up in the soffit during refills Air ...

Page 71: ... is the obligation of the customer to inform the local fire department about the dangers of magnetic fields These magnets stay at field for a long time even in a most blazing fire Ceiling sprinkler heads should be made of metal instead of glass A quench could falsely trigger the alcohol filled glass vials which can shatter in the presence of cold helium gas Sprinklers should not be located directl...

Page 72: ...Utility Requirements 72 H157655_1_008 ...

Page 73: ...netic Interference 52 To increase temperature stability the magnet should not be placed in direct sunlight or near any artificial heat source The magnet should also not be placed under or in close proximity to air vents or in an area that experiences air drafts Air should not be blown directly down or towards the NMR magnet When possible avoid a situation where a significant stray field 5 G 0 5 mT...

Page 74: ...5 68 MicroImaging Cabinet 0 69 0 83 1 55 205 150 BCU I 0 50 0 55 0 48 46 BCU II 0 55 0 59 0 74 74 Prodigy Unit 0 60 0 40 0 46 68 For the CryoProbe option refer to CryoProbe and Other Accessories 83 Table 9 1 Dimensions and Weights of NMR Equipment 9 3 Floor Load The floor must be sufficiently strong to support the mass of the equipment plus the weight of any installation devices e g hoists etc The...

Page 75: ...otal Weights table for the values of A B and C Magnet Type A Maximum Magnet Diameter m B Magnet Height from the Floor Including Stand m C Overall Footprint Diameter m2 Total Magnet Weight incl Stand Cryogens kg 400 54 Ascend Aeon 1 46 2 27 1 70 640 500 54 Ascend Aeon 1 46 2 27 1 70 740 600 54 Ascend Aeon 0 95 2 61 1 98 1060 700 54 Ascend Aeon 0 95 2 61 1 98 1360 With standard magnet stand the weig...

Page 76: ... devices that must be protected from Electrostatic Discharge ESD by proper floor covering and grounding practices To prevent ESD damage in the magnet room the system must be installed on an ESD resistant flooring such as vinyl and properly grounded One of the most important characteristics of an ESD resistant floor is its ability to conduct charges to ground The second most important aspect is its...

Page 77: ...must accommodate the magnet and provide safe access for sample insertion and cryogen fills Consult you Bruker office for further guidelines when using a magnet platform Figure 9 3 Example of a Simple Magnet Platform 9 7 Helium Flex Lines The purpose of the helium flex lines is to transport the helium gas from the compressor to the cold head and back The flex lines are isolated and are usually plac...

Page 78: ...he various units within the AVANCETM cabinet especially the acquisition computer must be kept at a minimum distance from the magnet Protection of the acquisition computer and digital electronics from the magnet s stray field is best achieved by positioning the cabinet so that the acquisition computer is no closer than the 1 0 mT 10 G line Any ancillary cabinets such as microimaging must also be pl...

Page 79: ...think about when creating a workable floor plan For ease of cabling locate electrical outlets and compressed air supply close to the rear of the cabinet and by the magnet The door to the magnet room must be easily accessible from all parts of the room It is advantageous to have the doors located so that traffic though the room does not approach the magnet The door to the magnet room should swing o...

Page 80: ...the NMR system components is presented in the chapter System Components 19 while the details regarding the utility requirements are presented in the chapter Utility Requirements 57 If a CryoProbe System is planned be sure to refer to CryoProbe and Other Accessories 83 for specific information on CryoProbe site requirements Figure 9 4 Ascend 400 Layout Example ...

Page 81: ... AVANCE Console 7 Preamplifier 2 Temperature Control Unit BCU I 8 Sample Changer 3 Magnet System 9 Damping Post for CryoProbe Transfer Line 4 0 5 mT 5 Gauss Line 10 He Gas Cylinder 6 0 for CryoPlatform 5 Operator s Desk 11 CryoPlatform 6 Cryocooler Cold Head with Noise Cover ...

Page 82: ...Floor Plan 82 H157655_1_008 ...

Page 83: ...es cryogenic cooling for the CryoProbe is made up of CryoCooling Unit with control electronics Helium Compressor along with any associated cooling equipment Helium Gas Cylinder for purging of the CryoProbe Helium transfer lines and transfer line support The CryoCooling Unit must be sited adjacent to the magnet whereas the Helium Compressor and Helium Gas Cylinder may be sited remotely The first st...

Page 84: ...CryoProbe and Other Accessories 84 H157655_1_008 Figure 10 1 CryoProbe System Overview Refer to the layout examples for more information ...

Page 85: ...cessory involves determining the type and location of the helium compressor Since the helium compressor generates a considerable amount of heat 7 5 kW average 8 5 kW peak it must be cooled to prevent overheating Bruker offers both water cooled and air cooled helium compressors In either case placing the compressor in a remote room allowing He gas flex lines up to 20 m to reach the CryoCooling unit...

Page 86: ...es to the He compressor should be fitted with temperature flow and pressure gauges that are visible The water hoses from the water lines to the He compressor should be 3 4 in size These hoses are not supplied with the CryoProbe system and are to be provided by the customer It is recommended to isolate the cooling water loop for the He compressor from the building water system by using either a ref...

Page 87: ...0 for 60Hz Quality pH Value Electrical Conductivity Chloride Ion Sulfate Ion M Alkalinity Total Hardness Calcium Hardness Ionic Silica Iron Copper Sulfide Ion Ammonium ion Residual Chlorine Free Carbon Dioxide Stability Index Suspended Matter Particle Size 6 5 to 8 2 at 25 C 77 F 80 mS m 200 mg liter 200 mg liter 100 mg liter 200 mg liter 150 mg liter 50 mg liter 1 0 mg liter 0 3 mg liter None Not...

Page 88: ...in the same room as the NMR is not recommended Ambient operating temperature 5 28ºC Figure 10 5 Helium Compressor Indoor Air Cooled 10 2 1 3 Helium Compressor Outdoor Air Cooled The Outdoor Air Cooled helium compressor consists of an Outdoor Unit and an Indoor Unit The outdoor unit is specified to operate between the temperatures of 30ºC to 45ºC Figure 10 6 Helium Compressor Outdoor Air Cooled ...

Page 89: ...deliverd to USA CA JP EU CH USA CA JP Operating Current 26 A 13 A 25 A Minimum Circuit Ampacity 35 A 17 A 35 A Maximum Fuse Size 60 A 30 A 60 A Compressor LRA 160 A 75 A 100 A Power Requirements Minimum Recommended 9 kVA 12 kVA 9 kVA 12 kVA 9 kVA 12 kVA Power Consumpton Cool Down max 50 60 Hz Steady State max 50 60 Hz 7 2 8 3 kW 6 5 7 5 kW 7 2 8 3 kW 6 5 7 5 kW 7 2 8 3 kW 6 5 7 2 kW Water supply t...

Page 90: ...m Height 92 cm Width 93 cm Depth 33 cm Height 92 cm Width 91 cm Depth 40 cm Height 105 cm Weight 142 kg 142 kg 115 kg Voltage 3 x 460 480 V 60 Hz 3 x 380 400 415 V 50 Hz 3 x 200 V 50 60 Hz 3 x 400 V 50 Hz Mainly delivered to EU CH USA CA JP EU CH Operating Current 13 A 30 A 13 A Minimum Circuit Ampacity 20 A 40 A 30 A Maximum Fuse Circuit Breaker Size 30 A 60 A 30 A Compressor LRA 13 A 30 A 74 A P...

Page 91: ...r and helium gas cylinder may be sited in a remote room or in the same room as the spectrometer as shown in the layout examples 10 4 Summary of CryoProbe Options Helium Compressors 3 Options Indoor Air Cooled Indoor Water Cooled Outdoor Air Cooled Helium Gas Transfer Lines For Indoor Helium Compressors 3 Options 6 m 10 m 20 m For Outdoor Helium Compressors 11 Options 3 m indoor line 10 m outdoor l...

Page 92: ...s must be supplied to helium compressor water cooled unit only Ambient operating temperature 5º 28ºC Note The indoor helium compressor has rollers and is connected to flexible helium transfer lines Water cooled models are additionally connected to water lines supplied by the customer typically high pressure flexible water tubing Helium Compressor Outdoor Air Cooled Consists of one small indoor uni...

Page 93: ...ntrol Unit PCU A liquid nitrogen vessel Figure 10 7 CryoProbe Prodigy and Control Unit Equipment Dimensions Prodigy Unit 60 x 40 x 46 cm3 L x W x H add 15 cm for rear connections LN2 Dewar 50 x 62 x 135 cm3 L x W x H width includes dewar handles Table 10 5 Prodigy System Equipment Dimensions Electrical Requirements Prodigy Unit 100 120 VAC 50 60 Hz max 10 A max 0 6 kW 220 240 VAC 50 60 Hz max 5 A ...

Page 94: ... bar Oil content 0 005 ppm 0 00425 mg m3 Solid impurities Use 5 micron filters filters should retain 99 99 of the specified particles Capacity 200 l min 7 cfm Case 3 Compressed air with dew point 25 C available Use an additional air dryer in order to obtain compressed air with a dew point 25 C 1 bar as specified in Case 2 above Bruker offers a membrane dryer with 60 l min 80 C P N 1808577 Backup N...

Page 95: ...e so that is located in the area of the NMR coils like a sample tube 10 6 2 Installation Requirements Two essential requirements have to be observed for the CryoFit 1 The CryoFit must be long enough to that it fits into the BST and the flow cell can reach the magnet center This requirement is automatically checked during the order review If a CryoFit is ordered as accessory for an already existing...

Page 96: ...CryoProbe and Other Accessories 96 H157655_1_008 ...

Page 97: ...hould only be opened by the Bruker BioSpin service engineer The commissioning of the magnet involves several stages as outlined in the table below The installation time line given below is an approximation each site is slightly different Duration Procedure ca 3 8 hours Transport fixtures are removed Cryostat is assembled 2 4 days The magnet is evacuated and flushed through with nitrogen 1 3 days C...

Page 98: ...V 16A USA 208V 30A single phase and two more 230V 16A USA 208V 20A single phase power outlets are needed to run a vacuum pump a heat gun and a power supply unit These power outlets must be available in addition to the main power source used to run the spectrometer ___ Step ladder non magnetic e g aluminum fiberglass or wood ___ Where possible the customer should provide the following Heat gun or h...

Page 99: ...he following A cylinder of helium gas 50l 4 6 grade 200 bar 2 cu ft 3000 psi 99 996 with secondary regulator value to deliver pressure of max 0 2 bar 3 psi Quantities of liquid helium as specified in the table found in Charging the Magnet 99 Liquid helium dewar 250 500 liter capacity with NW25 flange or suitable outlet compatible with the 10 mm 3 8 When ordering the helium the customer should arra...

Page 100: ...hat are ordered For standard stand weight will vary with optional stands Table 11 3 Magnet Transport Weights Standard Bore 54 mm Magnet Type Magnet Weight Empty with Magnet Stand kg Magnet Weight Filled with Magnet Stand kg LN2 Needed for Precool l LHe Needed for Cool down and Charging l LHe After a Training Quench l 400 89 Ascend Aeon 980 1050 800 500 500 500 89 Ascend Aeon 1060 1130 800 500 500 ...

Page 101: ...MR service centers Bruker BioSpin NMR provides dedicated hotlines and service centers so that our specialists can respond as quickly as possible to all your service requests applications questions software or technical needs Please select the NMR service center or hotline you wish to contact from our list available at https www bruker com service information communication helpdesk html ...

Page 102: ...Contact 102 H157655_1_008 ...

Page 103: ... 30 min Average Measurement 1 displayed in velocity 48 Figure 7 6 ADI Dampers 49 Figure 7 7 Tolerance Level Nano C for API Dampers 49 Figure 7 8 Example of the Bruker Tolerance Level for API Dampers Resolution 0 125 Hz 1 200 Hz 30 min Average Spectra Measurement 1 displayed in velocity 50 Figure 7 9 Schematic Drawing of an API Type Damping System 50 Figure 7 10 Specification Framework with the Mag...

Page 104: ...List of Figures 104 H157655_1_008 ...

Page 105: ... Fields Wide Bore 89 mm 40 Table 6 4 Vertical Stray Fields Standard Bore 54 mm 41 Table 6 5 Vertical Stray Fields Wide Bore 89 mm 41 Table 7 1 Application and Interpretation of the Generic Vibration Criterion VC Curves 44 Table 7 2 EMI Damping System Elastomeric Isolators 46 Table 7 3 ADI Damping System Elastomeric Isolators 48 Table 7 4 Tolerance Level for API Damping System 50 Table 7 5 Guidelin...

Page 106: ... System Equipment Dimensions 93 Table 10 6 Prodigy System Electrical Requirements 93 Table 10 7 Prodigy System N2 Gas Requirements 94 Table 10 8 Prodigy System Ventilation Requirements 94 Table 11 1 Overview of Magnet Commissioning 97 Table 11 2 Installation Requirements Checklist 98 Table 11 3 Magnet Transport Weights Standard Bore 54 mm 100 Table 11 4 Magnet Transport Weights Wide Bore 89 mm 100...

Page 107: ...6 Elevators 52 Emergency access 18 Emergency Plan 17 Emergency Sample Protection Device 59 ESD resistant flooring 76 External Disturbance Suppression 55 F Fans 43 Faraday cage 56 Ferromagnetic materials 51 Ferromagnetic objects 10 Fire extinguishers 18 71 Floor Types PVC 76 Vinyl 76 Wood 76 Fluxgate magnetometer 53 Fork Lift 31 G Gas cylinder 16 Gas cylinder storage 79 generator 57 Generators 43 H...

Page 108: ...tic field 9 Medically active implants 10 Safe handling of cryogenic liquids 15 Ventilation 14 Sample Changers 57 SampleCase 23 SampleJet 23 SampleXpress 23 Satellite systems 55 Satellites 52 Service access Magnet 79 Pulse Tube Cooler 79 Spectrometer 79 Solid Impurities 60 Standard Operating Procedures 17 Subways 52 Sunlight 73 Support beams 73 T Television broadcasts 55 Television stations 52 temp...

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Page 110: ...Bruker Corporation info bruker com www bruker com Order No H157655 ...